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@ARTICLE{Chattopadhyay:148721,
      author       = {S. Chattopadhyay$^*$ and G. Zheng$^*$ and A. Hemminki$^*$
                      and A. Försti$^*$ and K. Sundquist and J. Sundquist and K.
                      Hemminki$^*$},
      title        = {{I}nfluence of family history on risk of second primary
                      cancers and survival in squamous cell skin cancer patients.},
      journal      = {British journal of dermatology},
      volume       = {183},
      number       = {3},
      issn         = {1365-2133},
      address      = {Oxford},
      publisher    = {Wiley-Blackwell},
      reportid     = {DKFZ-2019-03247},
      pages        = {488-494},
      year         = {2020},
      note         = {2020 Sep;183(3):488-494 /
                      #EA:C050#EA:C020#LA:C050#LA:C020#},
      abstract     = {Squamous cell skin cancer (SCC) patients have excellent
                      prognosis but second primary cancers (SPCs) weaken survival
                      prospects. Family history is a known risk factor for cancer
                      but whether it is a risk factor for SPC in SCC patients is
                      not known.Quantify the risk of family history on SPCs in SCC
                      patients and estimate survival probabilities of patients
                      with SPCs depending on family history.With 13,945
                      histologically verified SCCs, relative risks (RRs) were
                      estimated for family history using a generalized regression
                      model. For survival analysis, hazard ratios were assessed
                      using a multivariable Cox-proportional hazard model.Family
                      history of invasive SCC increased risk of second invasive
                      SCC, RR = 42.92 (confidence intervals 33.69-50.32) compared
                      to risk without family history RR 19.12 (17.88-21.08).
                      Family history of any non-skin cancer in invasive SCC
                      increased risk of the same cancers to be diagnosed as SPC;
                      RRFH = 1.48 (1.35-1.61) vs. RRno FH = 1.40 (1.32-1.48);
                      significant increases were observed for seven different
                      non-skin cancers. Most results were replicated in in situ
                      SCC. SPC was deleterious for survival irrespective of family
                      history; hazard ratio for patients with SPC was 4.28
                      (3.83-4.72) compared to those without SPC (1.00).Family
                      history of non-skin cancer was associated with approximately
                      a doubling of risk for SPCs in SCC patients. SPC increases
                      the death rate in SCC patients 3 to 4 times, irrespective of
                      family history. Taking family history into account at SCC
                      diagnosis may help prevention or early detection of SPCs.},
      cin          = {C050 / C020 / B062 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C050-20160331 / I:(DE-He78)C020-20160331 /
                      I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31853941},
      doi          = {10.1111/bjd.18809},
      url          = {https://inrepo02.dkfz.de/record/148721},
}