%0 Journal Article
%A Tarakanchikova, Yana
%A Alzubi, Jamal
%A Pennucci, Valentina
%A Follo, Marie
%A Kochergin, Boris
%A Muslimov, Albert
%A Skovorodkin, Ilya
%A Vainio, Seppo
%A Antipina, Maria N
%A Atkin, Vsevolod
%A Popov, Alexey
%A Meglinski, Igor
%A Cathomen, Toni
%A Cornu, Tatjana I
%A Gorin, Dmitry A
%A Sukhorukov, Gleb B
%A Nazarenko, Irina
%T Biodegradable Nanocarriers Resembling Extracellular Vesicles Deliver Genetic Material with the Highest Efficiency to Various Cell Types.
%J Small
%V Dec
%@ 1613-6829
%C Weinheim
%I Wiley-VCH
%M DKFZ-2019-03252
%P e1904880
%D 2019
%Z Small. 2019 Dec 16:e1904880
%X Efficient delivery of genetic material to primary cells remains challenging. Here, efficient transfer of genetic material is presented using synthetic biodegradable nanocarriers, resembling extracellular vesicles in their biomechanical properties. This is based on two main technological achievements: generation of soft biodegradable polyelectrolyte capsules in nanosize and efficient application of the nanocapsules for co-transfer of different RNAs to tumor cell lines and primary cells, including hematopoietic progenitor cells and primary T cells. Near to 100
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31840408
%R 10.1002/smll.201904880
%U https://inrepo02.dkfz.de/record/148726