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000148726 1001_ $$aTarakanchikova, Yana$$b0
000148726 245__ $$aBiodegradable Nanocarriers Resembling Extracellular Vesicles Deliver Genetic Material with the Highest Efficiency to Various Cell Types.
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000148726 520__ $$aEfficient delivery of genetic material to primary cells remains challenging. Here, efficient transfer of genetic material is presented using synthetic biodegradable nanocarriers, resembling extracellular vesicles in their biomechanical properties. This is based on two main technological achievements: generation of soft biodegradable polyelectrolyte capsules in nanosize and efficient application of the nanocapsules for co-transfer of different RNAs to tumor cell lines and primary cells, including hematopoietic progenitor cells and primary T cells. Near to 100% efficiency is reached using only 2.5 × 10-4 pmol of siRNA, and 1 × 10-3 nmol of mRNA per cell, which is several magnitude orders below the amounts reported for any of methods published so far. The data show that biodegradable nanocapsules represent a universal and highly efficient biomimetic platform for the transfer of genetic material with the utmost potential to revolutionize gene transfer technology in vitro and in vivo.
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000148726 7001_ $$aAlzubi, Jamal$$b1
000148726 7001_ $$aPennucci, Valentina$$b2
000148726 7001_ $$aFollo, Marie$$b3
000148726 7001_ $$aKochergin, Boris$$b4
000148726 7001_ $$aMuslimov, Albert$$b5
000148726 7001_ $$aSkovorodkin, Ilya$$b6
000148726 7001_ $$aVainio, Seppo$$b7
000148726 7001_ $$aAntipina, Maria N$$b8
000148726 7001_ $$aAtkin, Vsevolod$$b9
000148726 7001_ $$aPopov, Alexey$$b10
000148726 7001_ $$aMeglinski, Igor$$b11
000148726 7001_ $$aCathomen, Toni$$b12
000148726 7001_ $$aCornu, Tatjana I$$b13
000148726 7001_ $$aGorin, Dmitry A$$b14
000148726 7001_ $$aSukhorukov, Gleb B$$b15
000148726 7001_ $$00000-0002-2633-1161$$aNazarenko, Irina$$b16
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