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@ARTICLE{AlSabah:148768,
      author       = {J. Al-Sabah$^*$ and C. Baccin and S. Haas$^*$},
      title        = {{S}ingle-cell and spatial transcriptomics approaches of the
                      bone marrow microenvironment.},
      journal      = {Current opinion in oncology},
      volume       = {32},
      number       = {2},
      issn         = {1040-8746},
      address      = {[S.l.]},
      publisher    = {Ovid},
      reportid     = {DKFZ-2019-03281},
      pages        = {146-153},
      year         = {2020},
      note         = {#EA:A010#LA:A010#DKFZ-ZMBH Alliance2020 Mar;32(2):146-153},
      abstract     = {The bone marrow is home to hematopoietic stem cells
                      responsible for lifelong blood production, alongside
                      mesenchymal stem cells required for skeletal regeneration.
                      In the bone marrow, a unique combination of signals derived
                      from a multitude of cell types results in the establishment
                      of so-called niches that regulate stem-cell maintenance and
                      differentiation. Recently, single-cell and spatially
                      resolved transcriptomics technologies have been utilized to
                      characterize the murine bone marrow microenvironment during
                      homeostasis, stress and upon cancer-induced remodeling. In
                      this review, we summarize the major findings of these
                      studies.Single-cell technologies applied to bone marrow
                      provided the first systematic and label-free identification
                      of bone marrow cell types, enabled their molecular and
                      spatial characterization, and clarified the cellular sources
                      of key prohematopoietic factors. Large transcriptional
                      heterogeneity and novel subpopulations were observed in
                      compartments previously thought to be homogenous. For
                      example, Lepr Cxcl12-abundant reticular cells were shown to
                      constitute the major source of prohematopoietic factors, but
                      consist of subpopulations differing in their adipogenic
                      versus osteogenic priming, morphology and localization.
                      These subpopulations were suggested to act as professional
                      cytokine secreting cells, thereby establishing distinct bone
                      marrow niches.Single-cell and spatially resolved
                      transcriptomics approaches have clarified the molecular
                      identity and localization of bone marrow-resident cell
                      types, paving the road for a deeper exploration of bone
                      marrow niches in the mouse and humans.},
      subtyp        = {Review Article},
      cin          = {A010 / V960},
      ddc          = {610},
      cid          = {I:(DE-He78)A010-20160331 / I:(DE-He78)V960-20160331},
      pnm          = {311 - Signalling pathways, cell and tumor biology
                      (POF3-311)},
      pid          = {G:(DE-HGF)POF3-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31833957},
      doi          = {10.1097/CCO.0000000000000602},
      url          = {https://inrepo02.dkfz.de/record/148768},
}