TY  - JOUR
AU  - Singhal, Mahak
AU  - Augustin, Hellmut
TI  - Beyond angiogenesis: Exploiting angiocrine factors to restrict tumor progression and metastasis.
JO  - Cancer research
VL  - 80
IS  - 4
SN  - 1538-7445
CY  - Philadelphia, Pa.
PB  - AACR
M1  - DKFZ-2019-03284
SP  - 659-662
PY  - 2020
N1  - DKFZ-ZMBH Alliance 2020 Feb 15;80(4):659-662#EA:A190#LA:A190#
AB  - Looking beyond tumor angiogenesis, the past decade has witnessed a fundamental change of paradigm with the discovery that the vascular endothelium does not just respond to exogenous cytokines, but exerts active 'angiocrine' gatekeeper roles controling their microenvironment in an instructive manner. While vascular niches host disseminated cancer cells and promote their stemness, endothelial cell-derived angiocrine signals orchestrate a favorable immune milieu to facilitate metastatic growth. Here, we discuss recent advances in the field of tumor microenvironment research and propose angiocrine signals as promising targets of future mechanism-driven anti-metastatic therapies, which may prove useful to synergistically combine with chemotherapy and immunotherapy.
LB  - PUB:(DE-HGF)16
C6  - pmid:31831463
DO  - DOI:10.1158/0008-5472.CAN-19-3351
UR  - https://inrepo02.dkfz.de/record/148771
ER  -