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@ARTICLE{Singhal:148771,
      author       = {M. Singhal$^*$ and H. Augustin$^*$},
      title        = {{B}eyond angiogenesis: {E}xploiting angiocrine factors to
                      restrict tumor progression and metastasis.},
      journal      = {Cancer research},
      volume       = {80},
      number       = {4},
      issn         = {1538-7445},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2019-03284},
      pages        = {659-662},
      year         = {2020},
      note         = {DKFZ-ZMBH Alliance 2020 Feb
                      15;80(4):659-662#EA:A190#LA:A190#},
      abstract     = {Looking beyond tumor angiogenesis, the past decade has
                      witnessed a fundamental change of paradigm with the
                      discovery that the vascular endothelium does not just
                      respond to exogenous cytokines, but exerts active
                      'angiocrine' gatekeeper roles controling their
                      microenvironment in an instructive manner. While vascular
                      niches host disseminated cancer cells and promote their
                      stemness, endothelial cell-derived angiocrine signals
                      orchestrate a favorable immune milieu to facilitate
                      metastatic growth. Here, we discuss recent advances in the
                      field of tumor microenvironment research and propose
                      angiocrine signals as promising targets of future
                      mechanism-driven anti-metastatic therapies, which may prove
                      useful to synergistically combine with chemotherapy and
                      immunotherapy.},
      cin          = {A190 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)A190-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {311 - Signalling pathways, cell and tumor biology
                      (POF3-311)},
      pid          = {G:(DE-HGF)POF3-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31831463},
      doi          = {10.1158/0008-5472.CAN-19-3351},
      url          = {https://inrepo02.dkfz.de/record/148771},
}