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@ARTICLE{Hovestadt:148789,
      author       = {V. Hovestadt and O. Ayrault and F. J. Swartling and G. W.
                      Robinson and S. Pfister$^*$ and P. A. Northcott},
      title        = {{M}edulloblastomics revisited: biological and clinical
                      insights from thousands of patients.},
      journal      = {Nature reviews / Cancer Cancer [...]},
      volume       = {20},
      number       = {1},
      issn         = {1474-1768},
      address      = {London [u.a.]},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2019-03302},
      pages        = {42 - 56},
      year         = {2020},
      abstract     = {Medulloblastoma, a malignant brain tumour primarily
                      diagnosed during childhood, has recently been the focus of
                      intensive molecular profiling efforts, profoundly advancing
                      our understanding of biologically and clinically
                      heterogeneous disease subgroups. Genomic, epigenomic,
                      transcriptomic and proteomic landscapes have now been mapped
                      for an unprecedented number of bulk samples from patients
                      with medulloblastoma and, more recently, for single
                      medulloblastoma cells. These efforts have provided pivotal
                      new insights into the diverse molecular mechanisms presumed
                      to drive tumour initiation, maintenance and recurrence
                      across individual subgroups and subtypes. Translational
                      opportunities stemming from this knowledge are continuing to
                      evolve, providing a framework for improved diagnostic and
                      therapeutic interventions. In this Review, we summarize
                      recent advances derived from this continued molecular
                      characterization of medulloblastoma and contextualize this
                      progress towards the deployment of more effective,
                      molecularly informed treatments for affected patients.},
      subtyp        = {Review Article},
      cin          = {B062 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31819232},
      doi          = {10.1038/s41568-019-0223-8},
      url          = {https://inrepo02.dkfz.de/record/148789},
}