%0 Journal Article
%A Catalano, Calogerina
%A da Silva Filho, Miguel Inacio
%A Frank, Christoph
%A Lu, Shun
%A Jiraskova, Katerina
%A Vymetalkova, Veronika
%A Levy, Miroslav
%A Liska, Vaclav
%A Vycital, Ondrej
%A Naccarati, Alessio
%A Vodickova, Ludmila
%A Hemminki, Kari
%A Vodicka, Pavel
%A Weber, Alexander N R
%A Försti, Asta
%T Epistatic effect of TLR3 and cGAS-STING-IKKε-TBK1-IFN signaling variants on colorectal cancer risk.
%J Cancer medicine
%V 9
%N 4
%@ 2045-7634
%C Hoboken, NJ
%I Wiley
%M DKFZ-2020-00007
%P 1473-1484
%D 2020
%Z 2020 Feb;9(4):1473-1484#EA:C050#LA:B062#LA:C050#
%X The TLR3/cGAS-STING-IFN signaling has recently been reported to be disturbed in colorectal cancer due to deregulated expression of the genes involved. Our study aimed to investigate the influence of potential regulatory variants in these genes on the risk of sporadic colorectal cancer (CRC) in a Czech cohort of 1424 CRC patients and 1114 healthy controls.The variants in the TLR3, CGAS, TMEM173, IKBKE, and TBK1 genes were selected using various online bioinformatic tools, such as UCSC browser, HaploReg, Regulome DB, Gtex Portal, SIFT, PolyPhen2, and miRNA prediction tools.Logistic regression analysis adjusted for age and sex detected a nominal association between CRC risk and three variants, CGAS rs72960018 (OR: 1.68, 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31869529
%R 10.1002/cam4.2804
%U https://inrepo02.dkfz.de/record/148815