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000148815 1001_ $$0P:(DE-He78)00b54a2735b6724e523a14642acac422$$aCatalano, Calogerina$$b0$$eFirst author$$udkfz
000148815 245__ $$aEpistatic effect of TLR3 and cGAS-STING-IKKε-TBK1-IFN signaling variants on colorectal cancer risk.
000148815 260__ $$aHoboken, NJ$$bWiley$$c2020
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000148815 500__ $$a2020 Feb;9(4):1473-1484#EA:C050#LA:B062#LA:C050#
000148815 520__ $$aThe TLR3/cGAS-STING-IFN signaling has recently been reported to be disturbed in colorectal cancer due to deregulated expression of the genes involved. Our study aimed to investigate the influence of potential regulatory variants in these genes on the risk of sporadic colorectal cancer (CRC) in a Czech cohort of 1424 CRC patients and 1114 healthy controls.The variants in the TLR3, CGAS, TMEM173, IKBKE, and TBK1 genes were selected using various online bioinformatic tools, such as UCSC browser, HaploReg, Regulome DB, Gtex Portal, SIFT, PolyPhen2, and miRNA prediction tools.Logistic regression analysis adjusted for age and sex detected a nominal association between CRC risk and three variants, CGAS rs72960018 (OR: 1.68, 95% CI: 1.11-2.53, P-value = .01), CGAS rs9352000 (OR: 2.02, 95% CI: 1.07-3.84, P-value = .03) and TMEM173 rs13153461 (OR: 1.53, 95% CI: 1.03-2.27, P-value = .03). Their cumulative effect revealed a threefold increased CRC risk in carriers of 5-6 risk alleles compared to those with 0-2 risk alleles. Epistatic interactions between these genes and the previously genotyped IFNAR1, IFNAR2, IFNA, IFNB, IFNK, IFNW, IRF3, and IRF7 genes, were computed to test their effect on CRC risk. Overall, we obtained nine pair-wise interactions within and between the CGAS, TMEM173, IKBKE, and TBK1 genes. Two of them remained statistically significant after Bonferroni correction. Additional 52 interactions were observed when IFN variants were added to the analysis.Our data suggest that epistatic interactions and a high number of risk alleles may play an important role in CRC carcinogenesis, offering novel biological understanding for the CRC management.
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000148815 7001_ $$0P:(DE-He78)58dd28059c2bb653eafa96d104065719$$ada Silva Filho, Miguel Inacio$$b1
000148815 7001_ $$0P:(DE-He78)78eb48d23c707bf44b051b0bdeae51d8$$aFrank, Christoph$$b2
000148815 7001_ $$00000-0002-1833-475X$$aLu, Shun$$b3
000148815 7001_ $$aJiraskova, Katerina$$b4
000148815 7001_ $$aVymetalkova, Veronika$$b5
000148815 7001_ $$aLevy, Miroslav$$b6
000148815 7001_ $$aLiska, Vaclav$$b7
000148815 7001_ $$aVycital, Ondrej$$b8
000148815 7001_ $$aNaccarati, Alessio$$b9
000148815 7001_ $$aVodickova, Ludmila$$b10
000148815 7001_ $$0P:(DE-He78)19b0ec1cea271419d9fa8680e6ed6865$$aHemminki, Kari$$b11$$udkfz
000148815 7001_ $$aVodicka, Pavel$$b12
000148815 7001_ $$aWeber, Alexander N R$$b13
000148815 7001_ $$0P:(DE-He78)f26164c08f2f14abcf31e52e13ee3696$$aFörsti, Asta$$b14$$eLast author$$udkfz
000148815 773__ $$0PERI:(DE-600)2659751-2$$a10.1002/cam4.2804$$gp. cam4.2804$$n4$$p1473-1484$$tCancer medicine$$v9$$x2045-7634$$y2020
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