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000148818 1001_ $$0P:(DE-He78)ce7d0cd1f5edc5c0e08c39b3fdd7b410$$aDeng, Maximilian Yuanzhe$$b0$$eFirst author$$udkfz
000148818 245__ $$aDiffuse Glioneuronal tumour with Oligodendroglioma-like features and Nuclear Clusters (DGONC) - a molecularly-defined glioneuronal CNS tumour class displaying recurrent monosomy 14.
000148818 260__ $$aOxford [u.a.]$$bWiley-Blackwell$$c2020
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000148818 520__ $$aDNA methylation-based central nervous system (CNS) tumour classification has identified numerous molecularly-distinct tumour types, and clinically relevant subgroups among known CNS tumour entities that were previously thought to represent homogeneous diseases. Our study aimed at characterising a novel, molecularly-defined variant of glioneuronal CNS tumour.DNA methylation profiling was performed using the Infinium MethylationEPIC or 450k BeadChip arrays (Illumina) and analysed using the 'conumee' package in R computing environment. Additional gene panel sequencing was also performed. Tumour samples were collected at the German Cancer Research Centre (DKFZ) and provided by multi-national collaborators. Histological sections were also collected and independently reviewed.Genome-wide DNA methylation data from >25,000 CNS tumours were screened for clusters separated from established DNA methylation classes, revealing a novel group comprising 31 tumours, mainly found in paediatric patients. This DNA methylation-defined variant of low-grade CNS tumours with glioneuronal differentiation displays recurrent monosomy 14, nuclear clusters within a morphology that is otherwise reminiscent of oligodendroglioma and other established entities with clear-cell histology, and a lack of genetic alterations commonly observed in other (paediatric) glioneuronal entities.DNA methylation-based tumour classification is an objective method of assessing tumour origins, which may aid in diagnosis, especially for atypical cases. With increasing sample size, methylation analysis allows for the identification of rare, putative new tumour entities, which are currently not recognized by the WHO classification. Our study revealed the existence of a DNA methylation-defined class of low-grade glioneuronal tumours with recurrent monosomy 14, oligodendroglioma-like features and nuclear clusters.
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000148818 7001_ $$0P:(DE-He78)45440b44791309bd4b7dbb4f73333f9b$$aSill, Martin$$b1$$udkfz
000148818 7001_ $$0P:(DE-He78)a46a5b2a871859c8e2d63d2f8c666807$$aSturm, Dominik$$b2$$udkfz
000148818 7001_ $$0P:(DE-He78)d20d08adc992abdb6ccffa1686f1ba17$$aStichel, Damian$$b3$$udkfz
000148818 7001_ $$0P:(DE-He78)046fd145f1008f83f6236580727bbc0f$$aWitt, Hendrik$$b4$$udkfz
000148818 7001_ $$0P:(DE-He78)3de637452ba900e2bdd359b8f41953bf$$aEcker, Jonas$$b5$$udkfz
000148818 7001_ $$0P:(DE-HGF)0$$aWittmann, Andreas$$b6
000148818 7001_ $$aSchittenhelm, Jens$$b7
000148818 7001_ $$aEbinger, Martin$$b8
000148818 7001_ $$aSchuhmann, Martin U$$b9
000148818 7001_ $$aFigarella-Branger, Dominique$$b10
000148818 7001_ $$aAronica, Eleonora$$b11
000148818 7001_ $$aStaszewski, Ori$$b12
000148818 7001_ $$aPreusser, Matthias$$b13
000148818 7001_ $$aHaberler, Christine$$b14
000148818 7001_ $$aLauten, Melchior$$b15
000148818 7001_ $$aSchüller, Ulrich$$b16
000148818 7001_ $$aHartmann, Christian$$b17
000148818 7001_ $$aSnuderl, Matija$$b18
000148818 7001_ $$aDunham, Christopher$$b19
000148818 7001_ $$aJabado, Nada$$b20
000148818 7001_ $$aWesseling, Pieter$$b21
000148818 7001_ $$aDeckert, Martina$$b22
000148818 7001_ $$aKeyvani, Kathy$$b23
000148818 7001_ $$aGottardo, Nick$$b24
000148818 7001_ $$aGiangaspero, Felice$$b25
000148818 7001_ $$avon Hoff, Katja$$b26
000148818 7001_ $$aEllison, David W$$b27
000148818 7001_ $$aPietsch, Torsten$$b28
000148818 7001_ $$aHerold Mende, Christel$$b29
000148818 7001_ $$0P:(DE-He78)0be2f86573954f87e97f8a4dbb05cb0f$$aMilde, Till$$b30$$udkfz
000148818 7001_ $$0P:(DE-He78)143af26de9d57bf624771616318aaf7c$$aWitt, Olaf$$b31$$udkfz
000148818 7001_ $$0P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8$$aKool, Marcel$$b32$$udkfz
000148818 7001_ $$0P:(DE-He78)8d9c904a6cea14d4c99c78ba46e41f93$$aKorshunov, Andrey$$b33$$udkfz
000148818 7001_ $$0P:(DE-He78)92e9783ca7025f36ce14e12cd348d2ee$$aWick, Wolfgang$$b34$$udkfz
000148818 7001_ $$0P:(DE-He78)a8a10626a848d31e70cfd96a133cc144$$avon Deimling, Andreas$$b35$$udkfz
000148818 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan M$$b36$$udkfz
000148818 7001_ $$0P:(DE-He78)551bb92841f634070997aa168d818492$$aJones, David T W$$b37$$udkfz
000148818 7001_ $$0P:(DE-He78)a1f4b408b9155beb2a8f7cba4d04fe88$$aSahm, Felix$$b38$$eLast author$$udkfz
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