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@ARTICLE{Deng:148818,
      author       = {M. Y. Deng$^*$ and M. Sill$^*$ and D. Sturm$^*$ and D.
                      Stichel$^*$ and H. Witt$^*$ and J. Ecker$^*$ and A.
                      Wittmann$^*$ and J. Schittenhelm and M. Ebinger and M. U.
                      Schuhmann and D. Figarella-Branger and E. Aronica and O.
                      Staszewski and M. Preusser and C. Haberler and M. Lauten and
                      U. Schüller and C. Hartmann and M. Snuderl and C. Dunham
                      and N. Jabado and P. Wesseling and M. Deckert and K. Keyvani
                      and N. Gottardo and F. Giangaspero and K. von Hoff and D. W.
                      Ellison and T. Pietsch and C. Herold Mende and T. Milde$^*$
                      and O. Witt$^*$ and M. Kool$^*$ and A. Korshunov$^*$ and W.
                      Wick$^*$ and A. von Deimling$^*$ and S. M. Pfister$^*$ and
                      D. T. W. Jones$^*$ and F. Sahm$^*$},
      title        = {{D}iffuse {G}lioneuronal tumour with
                      {O}ligodendroglioma-like features and {N}uclear {C}lusters
                      ({DGONC}) - a molecularly-defined glioneuronal {CNS} tumour
                      class displaying recurrent monosomy 14.},
      journal      = {Neuropathology $\&$ applied neurobiology},
      volume       = {46},
      number       = {5},
      issn         = {1365-2990},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {DKFZ-2020-00010},
      pages        = {422-430},
      year         = {2020},
      note         = {2020 Aug;46(5):422-430#EA:B360#LA:B300#},
      abstract     = {DNA methylation-based central nervous system (CNS) tumour
                      classification has identified numerous molecularly-distinct
                      tumour types, and clinically relevant subgroups among known
                      CNS tumour entities that were previously thought to
                      represent homogeneous diseases. Our study aimed at
                      characterising a novel, molecularly-defined variant of
                      glioneuronal CNS tumour.DNA methylation profiling was
                      performed using the Infinium MethylationEPIC or 450k
                      BeadChip arrays (Illumina) and analysed using the 'conumee'
                      package in R computing environment. Additional gene panel
                      sequencing was also performed. Tumour samples were collected
                      at the German Cancer Research Centre (DKFZ) and provided by
                      multi-national collaborators. Histological sections were
                      also collected and independently reviewed.Genome-wide DNA
                      methylation data from >25,000 CNS tumours were screened for
                      clusters separated from established DNA methylation classes,
                      revealing a novel group comprising 31 tumours, mainly found
                      in paediatric patients. This DNA methylation-defined variant
                      of low-grade CNS tumours with glioneuronal differentiation
                      displays recurrent monosomy 14, nuclear clusters within a
                      morphology that is otherwise reminiscent of
                      oligodendroglioma and other established entities with
                      clear-cell histology, and a lack of genetic alterations
                      commonly observed in other (paediatric) glioneuronal
                      entities.DNA methylation-based tumour classification is an
                      objective method of assessing tumour origins, which may aid
                      in diagnosis, especially for atypical cases. With increasing
                      sample size, methylation analysis allows for the
                      identification of rare, putative new tumour entities, which
                      are currently not recognized by the WHO classification. Our
                      study revealed the existence of a DNA methylation-defined
                      class of low-grade glioneuronal tumours with recurrent
                      monosomy 14, oligodendroglioma-like features and nuclear
                      clusters.},
      cin          = {B360 / B062 / HD01 / B300 / B310 / B320},
      ddc          = {610},
      cid          = {I:(DE-He78)B360-20160331 / I:(DE-He78)B062-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)B300-20160331 /
                      I:(DE-He78)B310-20160331 / I:(DE-He78)B320-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31867747},
      doi          = {10.1111/nan.12590},
      url          = {https://inrepo02.dkfz.de/record/148818},
}