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@ARTICLE{Deville:148819,
      author       = {S. S. Deville and N. Cordes$^*$},
      title        = {{T}he {E}xtracellular, {C}ellular, and {N}uclear
                      {S}tiffness, a {T}rinity in the {C}ancer {R}esistome-{A}
                      {R}eview.},
      journal      = {Frontiers in oncology},
      volume       = {9},
      issn         = {2234-943X},
      address      = {Lausanne},
      publisher    = {Frontiers Media},
      reportid     = {DKFZ-2020-00011},
      pages        = {1376},
      year         = {2019},
      note         = {LA:L301},
      abstract     = {Alterations in mechano-physiological properties of a tissue
                      instigate cancer burdens in parallel to common genetic and
                      epigenetic alterations. The chronological and mechanistic
                      interrelation between the various extra- and intracellular
                      aspects remains largely elusive. Mechano-physiologically,
                      integrins and other cell adhesion molecules present the main
                      mediators for transferring and distributing forces between
                      cells and the extracellular matrix (ECM). These cues are
                      channeled via focal adhesion proteins, termed the focal
                      adhesomes, to cytoskeleton and nucleus and vice versa
                      thereby affecting the pathophysiology of multicellular
                      cancer tissues. In combination with simultaneous activation
                      of diverse downstream signaling pathways, the phenotypes of
                      cancer cells are created and driven characterized by
                      deregulated transcriptional and biochemical cues that elicit
                      the hallmarks of cancer. It, however, remains unclear how
                      elastostatic modifications, i.e., stiffness, in the
                      extracellular, intracellular, and nuclear compartment
                      contribute and control the resistance of cancer cells to
                      therapy. In this review, we discuss how stiffness of unique
                      tumor components dictates therapy response and what is known
                      about the underlying molecular mechanisms.},
      subtyp        = {Review Article},
      cin          = {L301},
      ddc          = {610},
      cid          = {I:(DE-He78)L301-20160331},
      pnm          = {899 - ohne Topic (POF3-899)},
      pid          = {G:(DE-HGF)POF3-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31867279},
      pmc          = {pmc:PMC6908495},
      doi          = {10.3389/fonc.2019.01376},
      url          = {https://inrepo02.dkfz.de/record/148819},
}