%0 Journal Article
%A Archambault, Alexi N
%A Su, Yu-Ru
%A Jeon, Jihyoun
%A Thomas, Minta
%A Lin, Yi
%A Conti, David V
%A Win, Aung Ko
%A Sakoda, Lori C
%A Lansdorp-Vogelaar, Iris
%A Peterse, Elisabeth Fp
%A Zauber, Ann G
%A Duggan, David
%A Holowatyj, Andreana N
%A Huyghe, Jeroen R
%A Brenner, Hermann
%A Cotterchio, Michelle
%A Bézieau, Stéphane
%A Schmit, Stephanie L
%A Edlund, Christopher K
%A Southey, Melissa C
%A MacInnis, Robert J
%A Campbell, Peter T
%A Chang-Claude, Jenny
%A Slattery, Martha L
%A Chan, Andrew T
%A Joshi, Amit D
%A Song, Mingyang
%A Cao, Yin
%A Woods, Michael O
%A White, Emily
%A Weinstein, Stephanie J
%A Ulrich, Cornelia M
%A Hoffmeister, Michael
%A Bien, Stephanie A
%A Harrison, Tabitha A
%A Hampe, Jochen
%A Li, Christopher I
%A Schafmayer, Clemens
%A Offit, Kenneth
%A Pharoah, Paul D
%A Moreno, Victor
%A Lindblom, Annika
%A Wolk, Alicja
%A Wu, Anna H
%A Li, Li
%A Gunter, Marc J
%A Gsur, Andrea
%A Keku, Temitope O
%A Pearlman, Rachel
%A Bishop, D Timothy
%A Castellví-Bel, Sergi
%A Moreira, Leticia
%A Vodicka, Pavel
%A Kampman, Ellen
%A Giles, Graham G
%A Albanes, Demetrius
%A Baron, John A
%A Berndt, Sonja I
%A Brezina, Stefanie
%A Buch, Stephan
%A Buchanan, Daniel D
%A Trichopoulou, Antonia
%A Severi, Gianluca
%A Chirlaque, María-Dolores
%A Sánchez, Maria-José
%A Palli, Domenico
%A Kühn, Tilman
%A Murphy, Neil
%A Cross, Amanda J
%A Burnett-Hartman, Andrea N
%A Chanock, Stephen J
%A Chapelle, Albert de la
%A Easton, Douglas F
%A Elliott, Faye
%A English, Dallas R
%A Feskens, Edith Jm
%A FitzGerald, Liesel M
%A Goodman, Phyllis J
%A Hopper, John L
%A Hudson, Thomas J
%A Hunter, David J
%A Jacobs, Eric J
%A Joshu, Corinne E
%A Küry, Sébastien
%A Markowitz, Sanford D
%A Milne, Roger L
%A Platz, Elizabeth A
%A Rennert, Gad
%A Rennert, Hedy S
%A Schumacher, Fredrick R
%A Sandler, Robert S
%A Seminara, Daniela
%A Tangen, Catherine M
%A Thibodeau, Stephen N
%A Toland, Amanda E
%A van Duijnhoven, Franzel Jb
%A Visvanathan, Kala
%A Vodickova, Ludmila
%A Potter, John D
%A Männistö, Satu
%A Weigl, Korbinian
%A Figueiredo, Jane
%A Martín, Vicente
%A Larsson, Susanna C
%A Parfrey, Patrick S
%A Huang, Wen-Yi
%A Lenz, Heinz-Josef
%A Castelao, Jose E
%A Gago-Dominguez, Manuela
%A Muñoz-Garzón, Victor
%A Mancao, Christoph
%A Haiman, Christopher A
%A Wilkens, Lynne R
%A Siegel, Erin
%A Barry, Elizabeth
%A Younghusband, Ban
%A Van Guelpen, Bethany
%A Harlid, Sophia
%A Zeleniuch-Jacquotte, Anne
%A Liang, Peter S
%A Du, Mengmeng
%A Casey, Graham
%A Lindor, Noralane M
%A Le Marchand, Loic
%A Gallinger, Steven J
%A Jenkins, Mark A
%A Newcomb, Polly A
%A Gruber, Stephen B
%A Schoen, Robert E
%A Hampel, Heather
%A Corley, Douglas A
%A Hsu, Li
%A Peters, Ulrike
%A Hayes, Richard B
%T Cumulative Burden of Colorectal Cancer-Associated Genetic Variants is More Strongly Associated With Early-onset vs Late-onset Cancer.
%J Gastroenterology
%V 158
%N 5
%@ 0016-5085
%C Philadelphia, Pa. [u.a.]
%I Saunders
%M DKFZ-2020-00014
%P 1274-1286.e12
%D 2020
%Z 2020 Apr;158(5):1274-1286.e12.
%X Early-onset colorectal cancer (CRC, in persons younger than 50 years old) is increasing in incidence; yet, in the absence of a family history of CRC, this population lacks harmonized recommendations for prevention. We aimed to determine whether a polygenic risk score (PRS) developed from 95 CRC-associated common genetic risk variants was associated with risk for early-onset CRC.We studied risk for CRC associated with a weighted PRS in 12,197 participants younger than 50 years old vs 95,865 participants 50 years or older. PRS was calculated based on single-nucleotide polymorphisms associated with CRC in a large-scale genome-wide association study as of January 2019. Participants were pooled from 3 large consortia that provided clinical and genotyping data: the Colon Cancer Family Registry, the Colorectal Transdisciplinary study, and the Genetics and Epidemiology of Colorectal Cancer Consortium and were all of genetically defined European descent. Findings were replicated in an independent cohort of 72,573 participants.Overall associations with CRC per standard deviation of PRS were significant for early-onset cancer, and were stronger compared with late-onset cancer (P for interaction=.01); when we compared the highest PRS quartile with the lowest, risk increased 3.7-fold for early-onset CRC (95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31866242
%R 10.1053/j.gastro.2019.12.012
%U https://inrepo02.dkfz.de/record/148822