TY  - JOUR
AU  - Archambault, Alexi N
AU  - Su, Yu-Ru
AU  - Jeon, Jihyoun
AU  - Thomas, Minta
AU  - Lin, Yi
AU  - Conti, David V
AU  - Win, Aung Ko
AU  - Sakoda, Lori C
AU  - Lansdorp-Vogelaar, Iris
AU  - Peterse, Elisabeth Fp
AU  - Zauber, Ann G
AU  - Duggan, David
AU  - Holowatyj, Andreana N
AU  - Huyghe, Jeroen R
AU  - Brenner, Hermann
AU  - Cotterchio, Michelle
AU  - Bézieau, Stéphane
AU  - Schmit, Stephanie L
AU  - Edlund, Christopher K
AU  - Southey, Melissa C
AU  - MacInnis, Robert J
AU  - Campbell, Peter T
AU  - Chang-Claude, Jenny
AU  - Slattery, Martha L
AU  - Chan, Andrew T
AU  - Joshi, Amit D
AU  - Song, Mingyang
AU  - Cao, Yin
AU  - Woods, Michael O
AU  - White, Emily
AU  - Weinstein, Stephanie J
AU  - Ulrich, Cornelia M
AU  - Hoffmeister, Michael
AU  - Bien, Stephanie A
AU  - Harrison, Tabitha A
AU  - Hampe, Jochen
AU  - Li, Christopher I
AU  - Schafmayer, Clemens
AU  - Offit, Kenneth
AU  - Pharoah, Paul D
AU  - Moreno, Victor
AU  - Lindblom, Annika
AU  - Wolk, Alicja
AU  - Wu, Anna H
AU  - Li, Li
AU  - Gunter, Marc J
AU  - Gsur, Andrea
AU  - Keku, Temitope O
AU  - Pearlman, Rachel
AU  - Bishop, D Timothy
AU  - Castellví-Bel, Sergi
AU  - Moreira, Leticia
AU  - Vodicka, Pavel
AU  - Kampman, Ellen
AU  - Giles, Graham G
AU  - Albanes, Demetrius
AU  - Baron, John A
AU  - Berndt, Sonja I
AU  - Brezina, Stefanie
AU  - Buch, Stephan
AU  - Buchanan, Daniel D
AU  - Trichopoulou, Antonia
AU  - Severi, Gianluca
AU  - Chirlaque, María-Dolores
AU  - Sánchez, Maria-José
AU  - Palli, Domenico
AU  - Kühn, Tilman
AU  - Murphy, Neil
AU  - Cross, Amanda J
AU  - Burnett-Hartman, Andrea N
AU  - Chanock, Stephen J
AU  - Chapelle, Albert de la
AU  - Easton, Douglas F
AU  - Elliott, Faye
AU  - English, Dallas R
AU  - Feskens, Edith Jm
AU  - FitzGerald, Liesel M
AU  - Goodman, Phyllis J
AU  - Hopper, John L
AU  - Hudson, Thomas J
AU  - Hunter, David J
AU  - Jacobs, Eric J
AU  - Joshu, Corinne E
AU  - Küry, Sébastien
AU  - Markowitz, Sanford D
AU  - Milne, Roger L
AU  - Platz, Elizabeth A
AU  - Rennert, Gad
AU  - Rennert, Hedy S
AU  - Schumacher, Fredrick R
AU  - Sandler, Robert S
AU  - Seminara, Daniela
AU  - Tangen, Catherine M
AU  - Thibodeau, Stephen N
AU  - Toland, Amanda E
AU  - van Duijnhoven, Franzel Jb
AU  - Visvanathan, Kala
AU  - Vodickova, Ludmila
AU  - Potter, John D
AU  - Männistö, Satu
AU  - Weigl, Korbinian
AU  - Figueiredo, Jane
AU  - Martín, Vicente
AU  - Larsson, Susanna C
AU  - Parfrey, Patrick S
AU  - Huang, Wen-Yi
AU  - Lenz, Heinz-Josef
AU  - Castelao, Jose E
AU  - Gago-Dominguez, Manuela
AU  - Muñoz-Garzón, Victor
AU  - Mancao, Christoph
AU  - Haiman, Christopher A
AU  - Wilkens, Lynne R
AU  - Siegel, Erin
AU  - Barry, Elizabeth
AU  - Younghusband, Ban
AU  - Van Guelpen, Bethany
AU  - Harlid, Sophia
AU  - Zeleniuch-Jacquotte, Anne
AU  - Liang, Peter S
AU  - Du, Mengmeng
AU  - Casey, Graham
AU  - Lindor, Noralane M
AU  - Le Marchand, Loic
AU  - Gallinger, Steven J
AU  - Jenkins, Mark A
AU  - Newcomb, Polly A
AU  - Gruber, Stephen B
AU  - Schoen, Robert E
AU  - Hampel, Heather
AU  - Corley, Douglas A
AU  - Hsu, Li
AU  - Peters, Ulrike
AU  - Hayes, Richard B
TI  - Cumulative Burden of Colorectal Cancer-Associated Genetic Variants is More Strongly Associated With Early-onset vs Late-onset Cancer.
JO  - Gastroenterology
VL  - 158
IS  - 5
SN  - 0016-5085
CY  - Philadelphia, Pa. [u.a.]
PB  - Saunders
M1  - DKFZ-2020-00014
SP  - 1274-1286.e12
PY  - 2020
N1  - 2020 Apr;158(5):1274-1286.e12.
AB  - Early-onset colorectal cancer (CRC, in persons younger than 50 years old) is increasing in incidence; yet, in the absence of a family history of CRC, this population lacks harmonized recommendations for prevention. We aimed to determine whether a polygenic risk score (PRS) developed from 95 CRC-associated common genetic risk variants was associated with risk for early-onset CRC.We studied risk for CRC associated with a weighted PRS in 12,197 participants younger than 50 years old vs 95,865 participants 50 years or older. PRS was calculated based on single-nucleotide polymorphisms associated with CRC in a large-scale genome-wide association study as of January 2019. Participants were pooled from 3 large consortia that provided clinical and genotyping data: the Colon Cancer Family Registry, the Colorectal Transdisciplinary study, and the Genetics and Epidemiology of Colorectal Cancer Consortium and were all of genetically defined European descent. Findings were replicated in an independent cohort of 72,573 participants.Overall associations with CRC per standard deviation of PRS were significant for early-onset cancer, and were stronger compared with late-onset cancer (P for interaction=.01); when we compared the highest PRS quartile with the lowest, risk increased 3.7-fold for early-onset CRC (95
LB  - PUB:(DE-HGF)16
C6  - pmid:31866242
DO  - DOI:10.1053/j.gastro.2019.12.012
UR  - https://inrepo02.dkfz.de/record/148822
ER  -