000148828 001__ 148828
000148828 005__ 20240229123035.0
000148828 0247_ $$2doi$$a10.1038/s41556-019-0439-6
000148828 0247_ $$2pmid$$apmid:31871321
000148828 0247_ $$2ISSN$$a1465-7392
000148828 0247_ $$2ISSN$$a1476-4679
000148828 0247_ $$2altmetric$$aaltmetric:73175394
000148828 037__ $$aDKFZ-2020-00020
000148828 041__ $$aeng
000148828 082__ $$a570
000148828 1001_ $$00000-0003-1251-6947$$aBaccin, Chiara$$b0
000148828 245__ $$aCombined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization.
000148828 260__ $$aNew York, NY$$bNature America$$c2020
000148828 3367_ $$2DRIVER$$aarticle
000148828 3367_ $$2DataCite$$aOutput Types/Journal article
000148828 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1634816177_21237
000148828 3367_ $$2BibTeX$$aARTICLE
000148828 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000148828 3367_ $$00$$2EndNote$$aJournal Article
000148828 500__ $$aDKFZ-ZMBH Alliance2020 Jan;22(1):38-48#LA:A010#
000148828 520__ $$aThe bone marrow constitutes the primary site for life-long blood production and skeletal regeneration. However, its cellular and spatial organization remains controversial. Here, we combine single-cell and spatially resolved transcriptomics to systematically map the molecular, cellular and spatial composition of distinct bone marrow niches. This allowed us to transcriptionally profile all major bone-marrow-resident cell types, determine their localization and clarify sources of pro-haematopoietic factors. Our data demonstrate that Cxcl12-abundant-reticular (CAR) cell subsets (Adipo-CAR and Osteo-CAR) differentially localize to sinusoidal and arteriolar surfaces, act locally as 'professional cytokine-secreting cells' and thereby establish peri-vascular micro-niches. Importantly, the three-dimensional bone-marrow organization can be accurately inferred from single-cell transcriptome data using the RNA-Magnet algorithm described here. Together, our study reveals the cellular and spatial organization of bone marrow niches and offers a systematic approach to dissect the complex organization of whole organs.
000148828 536__ $$0G:(DE-HGF)POF3-311$$a311 - Signalling pathways, cell and tumor biology (POF3-311)$$cPOF3-311$$fPOF III$$x0
000148828 588__ $$aDataset connected to CrossRef, PubMed,
000148828 7001_ $$0P:(DE-He78)390ea815e61688e5fee33b98ed4180eb$$aAl-Sabah, Jude$$b1$$eFirst author
000148828 7001_ $$00000-0002-1233-5874$$aVelten, Lars$$b2
000148828 7001_ $$00000-0001-6488-2805$$aHelbling, Patrick M$$b3
000148828 7001_ $$0P:(DE-He78)6b879b5f67d8b3bcdffc7c01cbf8d1f1$$aGrünschläger, Florian$$b4
000148828 7001_ $$00000-0003-4529-384X$$aHernández-Malmierca, Pablo$$b5
000148828 7001_ $$00000-0003-0415-259X$$aNombela-Arrieta, César$$b6
000148828 7001_ $$00000-0002-3962-2865$$aSteinmetz, Lars M$$b7
000148828 7001_ $$0P:(DE-He78)732f4fbcddb0042251aa759a2e74d3b2$$aTrumpp, Andreas$$b8$$eLast author
000148828 7001_ $$0P:(DE-He78)a5ec4e2fef99022a37a6b07c2fdd6325$$aHaas, Simon$$b9$$eLast author
000148828 773__ $$0PERI:(DE-600)1494945-3$$a10.1038/s41556-019-0439-6$$n1$$p38-48$$tNature cell biology$$v22$$x1476-4679$$y2020
000148828 909CO $$ooai:inrepo02.dkfz.de:148828$$pVDB
000148828 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)390ea815e61688e5fee33b98ed4180eb$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000148828 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)6b879b5f67d8b3bcdffc7c01cbf8d1f1$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000148828 9101_ $$0I:(DE-588b)2036810-0$$60000-0003-4529-384X$$aDeutsches Krebsforschungszentrum$$b5$$kDKFZ
000148828 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)732f4fbcddb0042251aa759a2e74d3b2$$aDeutsches Krebsforschungszentrum$$b8$$kDKFZ
000148828 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)a5ec4e2fef99022a37a6b07c2fdd6325$$aDeutsches Krebsforschungszentrum$$b9$$kDKFZ
000148828 9131_ $$0G:(DE-HGF)POF3-311$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vSignalling pathways, cell and tumor biology$$x0
000148828 9141_ $$y2020
000148828 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000148828 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000148828 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000148828 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNAT CELL BIOL : 2017
000148828 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000148828 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000148828 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000148828 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000148828 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000148828 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000148828 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000148828 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000148828 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000148828 915__ $$0StatID:(DE-HGF)9915$$2StatID$$aIF >= 15$$bNAT CELL BIOL : 2017
000148828 9202_ $$0I:(DE-He78)A010-20160331$$kA010$$lA010 Stammzellen und Krebs$$x0
000148828 9201_ $$0I:(DE-He78)A010-20160331$$kA010$$lA010 Stammzellen und Krebs$$x0
000148828 9201_ $$0I:(DE-He78)V960-20160331$$kV960$$lV960 HI-Stem$$x1
000148828 9201_ $$0I:(DE-He78)HD01-20160331$$kHD01$$lDKTK HD zentral$$x2
000148828 980__ $$ajournal
000148828 980__ $$aVDB
000148828 980__ $$aI:(DE-He78)A010-20160331
000148828 980__ $$aI:(DE-He78)V960-20160331
000148828 980__ $$aI:(DE-He78)HD01-20160331
000148828 980__ $$aUNRESTRICTED