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@ARTICLE{Baccin:148828,
      author       = {C. Baccin and J. Al-Sabah$^*$ and L. Velten and P. M.
                      Helbling and F. Grünschläger$^*$ and P.
                      Hernández-Malmierca$^*$ and C. Nombela-Arrieta and L. M.
                      Steinmetz and A. Trumpp$^*$ and S. Haas$^*$},
      title        = {{C}ombined single-cell and spatial transcriptomics reveal
                      the molecular, cellular and spatial bone marrow niche
                      organization.},
      journal      = {Nature cell biology},
      volume       = {22},
      number       = {1},
      issn         = {1476-4679},
      address      = {New York, NY},
      publisher    = {Nature America},
      reportid     = {DKFZ-2020-00020},
      pages        = {38-48},
      year         = {2020},
      note         = {DKFZ-ZMBH Alliance2020 Jan;22(1):38-48#LA:A010#},
      abstract     = {The bone marrow constitutes the primary site for life-long
                      blood production and skeletal regeneration. However, its
                      cellular and spatial organization remains controversial.
                      Here, we combine single-cell and spatially resolved
                      transcriptomics to systematically map the molecular,
                      cellular and spatial composition of distinct bone marrow
                      niches. This allowed us to transcriptionally profile all
                      major bone-marrow-resident cell types, determine their
                      localization and clarify sources of pro-haematopoietic
                      factors. Our data demonstrate that Cxcl12-abundant-reticular
                      (CAR) cell subsets (Adipo-CAR and Osteo-CAR) differentially
                      localize to sinusoidal and arteriolar surfaces, act locally
                      as 'professional cytokine-secreting cells' and thereby
                      establish peri-vascular micro-niches. Importantly, the
                      three-dimensional bone-marrow organization can be accurately
                      inferred from single-cell transcriptome data using the
                      RNA-Magnet algorithm described here. Together, our study
                      reveals the cellular and spatial organization of bone marrow
                      niches and offers a systematic approach to dissect the
                      complex organization of whole organs.},
      cin          = {A010 / V960 / HD01},
      ddc          = {570},
      cid          = {I:(DE-He78)A010-20160331 / I:(DE-He78)V960-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {311 - Signalling pathways, cell and tumor biology
                      (POF3-311)},
      pid          = {G:(DE-HGF)POF3-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31871321},
      doi          = {10.1038/s41556-019-0439-6},
      url          = {https://inrepo02.dkfz.de/record/148828},
}