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000148843 037__ $$aDKFZ-2020-00035
000148843 041__ $$aeng
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000148843 1001_ $$aBreitkopf, Daniel M$$b0
000148843 245__ $$aThe YB-1:Notch-3 axis modulates immune cell responses and organ damage in systemic lupus erythematosus.
000148843 260__ $$aNew York, NY$$bElsevier$$c2020
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000148843 500__ $$a2020 Feb;97(2):289-303
000148843 520__ $$aSystemic lupus erythematosus (SLE) is an autoimmune disease and lupus nephritis is a major risk factor for morbidity and mortality. Notch-3 signaling induced by membrane-bound or soluble ligands such as YB-1 constitutes an evolutionarily conserved pathway that determines major decisions in cell fate. Mass spectrometry of extracellular YB-1 in sera from patients with SLE and lupus-prone mice revealed specific post-translational guanidinylation of two lysine residues within the highly conserved cold-shock domain of YB-1 (YB-1-G). These modifications highly correlated with SLE disease activity, especially in patients with lupus nephritis and resulted in enhanced activation of Notch-3 signaling in T lymphocytes. The importance of YB-1:Notch-3 interaction in T cells was further evidenced by increased interleukin (Il)10 expression following YB-1-G stimulation and detection of both, YB-1-G and Notch-3, in kidneys of MRL.lpr mice by mass spectrometry imaging. Notch-3 expression and activation was significantly up-regulated in kidneys of 20-week-old MRL.lpr mice. Notably, lupus-prone mice with constitutional Notch-3 depletion (B6.Faslpr/lprNotch3-/-) exhibited an aggravated lupus phenotype with significantly increased mortality, enlarged lymphoid organs and aggravated nephritis. Additionally, these mice displayed fewer regulatory T cells and reduced amounts of anti-inflammatory IL-10. Thus, our results indicate that the YB-1:Notch-3 axis exerts protective effects in SLE and that Notch-3 deficiency exacerbates the SLE phenotype.
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000148843 7001_ $$aJankowski, Vera$$b1
000148843 7001_ $$aOhl, Kim$$b2
000148843 7001_ $$aHermann, Juliane$$b3
000148843 7001_ $$aHermert, Daniela$$b4
000148843 7001_ $$aTenbrock, Klaus$$b5
000148843 7001_ $$aLiu, Xiyang$$b6
000148843 7001_ $$aMartin, Ina V$$b7
000148843 7001_ $$aWang, Jialin$$b8
000148843 7001_ $$aGroll, Fabian$$b9
000148843 7001_ $$0P:(DE-He78)b72c4ee15f75cf6944080c339a34475b$$aGröne, Elisabeth$$b10$$udkfz
000148843 7001_ $$aFloege, Jürgen$$b11
000148843 7001_ $$aOstendorf, Tammo$$b12
000148843 7001_ $$aRauen, Thomas$$b13
000148843 7001_ $$aRaffetseder, Ute$$b14
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