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| Home > Publications database > The YB-1:Notch-3 axis modulates immune cell responses and organ damage in systemic lupus erythematosus. > print |
| Home > Publications database > The YB-1:Notch-3 axis modulates immune cell responses and organ damage in systemic lupus erythematosus. > print |
| 001 | 148843 | ||
| 005 | 20240229123036.0 | ||
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| 100 | 1 | _ | |a Breitkopf, Daniel M |b 0 |
| 245 | _ | _ | |a The YB-1:Notch-3 axis modulates immune cell responses and organ damage in systemic lupus erythematosus. |
| 260 | _ | _ | |a New York, NY |c 2020 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a 2020 Feb;97(2):289-303 |
| 520 | _ | _ | |a Systemic lupus erythematosus (SLE) is an autoimmune disease and lupus nephritis is a major risk factor for morbidity and mortality. Notch-3 signaling induced by membrane-bound or soluble ligands such as YB-1 constitutes an evolutionarily conserved pathway that determines major decisions in cell fate. Mass spectrometry of extracellular YB-1 in sera from patients with SLE and lupus-prone mice revealed specific post-translational guanidinylation of two lysine residues within the highly conserved cold-shock domain of YB-1 (YB-1-G). These modifications highly correlated with SLE disease activity, especially in patients with lupus nephritis and resulted in enhanced activation of Notch-3 signaling in T lymphocytes. The importance of YB-1:Notch-3 interaction in T cells was further evidenced by increased interleukin (Il)10 expression following YB-1-G stimulation and detection of both, YB-1-G and Notch-3, in kidneys of MRL.lpr mice by mass spectrometry imaging. Notch-3 expression and activation was significantly up-regulated in kidneys of 20-week-old MRL.lpr mice. Notably, lupus-prone mice with constitutional Notch-3 depletion (B6.Faslpr/lprNotch3-/-) exhibited an aggravated lupus phenotype with significantly increased mortality, enlarged lymphoid organs and aggravated nephritis. Additionally, these mice displayed fewer regulatory T cells and reduced amounts of anti-inflammatory IL-10. Thus, our results indicate that the YB-1:Notch-3 axis exerts protective effects in SLE and that Notch-3 deficiency exacerbates the SLE phenotype. |
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| 700 | 1 | _ | |a Jankowski, Vera |b 1 |
| 700 | 1 | _ | |a Ohl, Kim |b 2 |
| 700 | 1 | _ | |a Hermann, Juliane |b 3 |
| 700 | 1 | _ | |a Hermert, Daniela |b 4 |
| 700 | 1 | _ | |a Tenbrock, Klaus |b 5 |
| 700 | 1 | _ | |a Liu, Xiyang |b 6 |
| 700 | 1 | _ | |a Martin, Ina V |b 7 |
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| 700 | 1 | _ | |a Rauen, Thomas |b 13 |
| 700 | 1 | _ | |a Raffetseder, Ute |b 14 |
| 773 | _ | _ | |a 10.1016/j.kint.2019.09.031 |g p. S0085253819310397 |0 PERI:(DE-600)2007940-0 |n 2 |p 289-303 |t Kidney international |v 97 |y 2020 |x 0085-2538 |
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