TY  - JOUR
AU  - Murphy, Neil
AU  - Carreras-Torres, Robert
AU  - Song, Mingyang
AU  - Chan, Andrew T
AU  - Martin, Richard M
AU  - Papadimitriou, Nikos
AU  - Dimou, Niki
AU  - Tsilidis, Konstantinos K
AU  - Banbury, Barbara
AU  - Bradbury, Kathryn E
AU  - Besevic, Jelena
AU  - Rinaldi, Sabina
AU  - Riboli, Elio
AU  - Cross, Amanda J
AU  - Travis, Ruth C
AU  - Agnoli, Claudia
AU  - Albanes, Demetrius
AU  - Berndt, Sonja I
AU  - Bézieau, Stéphane
AU  - Bishop, D Timothy
AU  - Brenner, Hermann
AU  - Buchanan, Daniel D
AU  - Onland-Moret, N Charlotte
AU  - Burnett-Hartman, Andrea
AU  - Campbell, Peter T
AU  - Casey, Graham
AU  - Castellví-Bel, Sergi
AU  - Chang-Claude, Jenny
AU  - Chirlaque, María-Dolores
AU  - Chapelle, Albert de la
AU  - English, Dallas
AU  - Figueiredo, Jane C
AU  - Gallinger, Steven J
AU  - Giles, Graham G
AU  - Gruber, Stephen B
AU  - Gsur, Andrea
AU  - Hampe, Jochen
AU  - Hampel, Heather
AU  - Harrison, Tabitha A
AU  - Hoffmeister, Michael
AU  - Hsu, Li
AU  - Huang, Wen-Yi
AU  - Huyghe, Jeroen R
AU  - Jenkins, Mark A
AU  - Keku, Temitope O
AU  - Kühn, Tilman
AU  - Kweon, Sun-Seog
AU  - Le Marchand, Loic
AU  - Li, Christopher I
AU  - Li, Li
AU  - Lindblom, Annika
AU  - Martín, Vicente
AU  - Milne, Roger L
AU  - Moreno, Victor
AU  - Newcomb, Polly A
AU  - Offit, Kenneth
AU  - Ogino, Shuji
AU  - Ose, Jennifer
AU  - Perduca, Vittorio
AU  - Phipps, Amanda I
AU  - Platz, Elizabeth A
AU  - Potter, John D
AU  - Qu, Conghui
AU  - Rennert, Gad
AU  - Sakoda, Lori C
AU  - Schafmayer, Clemens
AU  - Schoen, Robert E
AU  - Slattery, Martha L
AU  - Tangen, Catherine M
AU  - Ulrich, Cornelia M
AU  - van Duijnhoven, Franzel Jb
AU  - Van Guelpen, Bethany
AU  - Visvanathan, Kala
AU  - Vodicka, Pavel
AU  - Vodickova, Ludmila
AU  - Vymetalkova, Veronika
AU  - Wang, Hansong
AU  - White, Emily
AU  - Wolk, Alicja
AU  - Woods, Michael O
AU  - Wu, Anna H
AU  - Zheng, Wei
AU  - Peters, Ulrike
AU  - Gunter, Marc J
TI  - Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses.
JO  - Gastroenterology
VL  - 158
IS  - 5
SN  - 0016-5085
CY  - Philadelphia, Pa. [u.a.]
PB  - Saunders
M1  - DKFZ-2020-00038
SP  - 1300-1312.e20
PY  - 2020
N1  - 2020 Apr;158(5):1300-1312.e20
AB  - Human studies examining associations between circulating levels of insulin-like growth factor 1 (IGF1) and insulin-like growth factor binding protein 3 (IGFBP3) and colorectal cancer risk have reported inconsistent results. We conducted complementary serologic and Mendelian randomization (MR) analyses to determine whether alterations in circulating levels of IGF1 or IGFBP3 are associated with colorectal cancer development.Serum levels of IGF1 and other proteins were measured in blood samples collected from 397,380 participants from the UK Biobank, from 2006 through 2010. Incident cancer cases and cancer cases recorded first in death certificates were identified through linkage to national cancer and death registries. Complete follow up was available through March 31, 2016. For the MR analyses, we identified genetic variants associated with circulating levels of IGF1 and IGFBP3. The association of these genetic variants with colorectal cancer was examined with 2-sample MR methods using genome-wide association study consortia data (52,865 cases with colorectal cancer and 46,287 individuals without [controls]) RESULTS: After a median follow-up period of 7.1 years, 2665 cases of colorectal cancer were recorded. In a multivariable-adjusted model, circulating level of IGF1 level associated with colorectal cancer risk (hazard ratio per 1 standard deviation increment of IGF1, 1.11; 95
LB  - PUB:(DE-HGF)16
C6  - pmid:31884074
DO  - DOI:10.1053/j.gastro.2019.12.020
UR  - https://inrepo02.dkfz.de/record/148846
ER  -