%0 Journal Article
%A Eulitz, J.
%A Lutz, B.
%A Wohlfahrt, P.
%A Dutz, A.
%A Enghardt, W.
%A Karpowitz, C.
%A Krause, M.
%A Troost, E. G. C.
%A Lühr, A.
%T A Monte Carlo based radiation response modelling framework to assess variability of clinical RBE in proton therapy.
%J Physics in medicine and biology
%V 64
%N 22
%@ 1361-6560
%C Bristol
%I IOP Publ.
%M DKFZ-2020-00052
%P 225020 
%D 2019
%X The clinical implementation of a variable relative biological effectiveness (RBE) in proton therapy is currently controversially discussed. Initial clinical evidence indicates a variable proton RBE, which needs to be verified. In this study, a radiation response modelling framework for assessing clinical RBE variability is established. It was applied to four selected glioma patients (grade III) treated with adjuvant radio(chemo)therapy and who developed late morphological image changes on T1-weighted contrast-enhanced (T1w-CE) magnetic resonance (MR) images within approximately two years of recurrence-free follow-up. The image changes were correlated voxelwise with dose and linear energy transfer (LET) values using univariable and multivariable logistic regression analysis. The regression models were evaluated by the area-under-the-curve (AUC) method performing a leave-one-out cross validation. The tolerance dose TD50 at which 50
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31374558
%R 10.1088/1361-6560/ab3841
%U https://inrepo02.dkfz.de/record/148860