%0 Journal Article
%A May, Verena
%A Berchtold, Susanne
%A Berger, Alexander
%A Venturelli, Sascha
%A Burkard, Markus
%A Leischner, Christian
%A Malek, Nisar P
%A Lauer, Ulrich M
%T Chemovirotherapy for pancreatic cancer: Gemcitabine plus oncolytic measles vaccine virus.
%J Oncology letters
%V 18
%N 5
%@ 1792-1082
%C Athens
%I Spandidos Publ.
%M DKFZ-2020-00068
%P 5534-5542
%D 2019
%Z LA:L801
%X Oncolytic virotherapy with vaccine viruses employs replicative vectors, which quite selectively infect tumor cells leading to massive virus replication followed by subsequent profound tumor cell death (oncolysis). Measles vaccine virus (MeV) has already shown great oncolytic activity against different types of cancers, including pancreatic cancer. Gemcitabine is a first line chemotherapeutic drug used for pancreatic cancer in palliative treatment plans. Furthermore, this drug can be used to induce senescence, a permanent cell cycle arrest, in tumor cells. In our preclinical work, three well-characterized immortalized human pancreatic cancer cell lines were used to investigate the combinatorial effect of MeV-based virotherapy together with the chemotherapeutic compound gemcitabine. Viability assays revealed that the combination of only small amounts of MeV together with subtherapeutic concentrations of gemcitabine resulted in a tumor cell mass reduction of >50
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31612061
%2 pmc:PMC6781561
%R 10.3892/ol.2019.10901
%U https://inrepo02.dkfz.de/record/148910