TY  - JOUR
AU  - Pertesi, Maroulio
AU  - Went, Molly
AU  - Hansson, Markus
AU  - Hemminki, Kari
AU  - Houlston, Richard S
AU  - Nilsson, Björn
TI  - Genetic predisposition for multiple myeloma.
JO  - Leukemia
VL  - 34
IS  - 3
SN  - 1476-5551
CY  - London
PB  - Springer Nature
M1  - DKFZ-2020-00127
SP  - 697-708
PY  - 2020
N1  - 2020 Mar;34(3):697-708
AB  - Multiple myeloma (MM) is the second most common blood malignancy. Epidemiological family studies going back to the 1920s have provided evidence for familial aggregation, suggesting a subset of cases have an inherited genetic background. Recently, studies aimed at explaining this phenomenon have begun to provide direct evidence for genetic predisposition to MM. Genome-wide association studies have identified common risk alleles at 24 independent loci. Sequencing studies of familial cases and kindreds have begun to identify promising candidate genes where variants with strong effects on MM risk might reside. Finally, functional studies are starting to give insight into how identified risk alleles promote the development of MM. Here, we review recent findings in MM predisposition field, and highlight open questions and future directions.
LB  - PUB:(DE-HGF)16
C6  - pmid:31913320
DO  - DOI:10.1038/s41375-019-0703-6
UR  - https://inrepo02.dkfz.de/record/153045
ER  -