%0 Journal Article
%A Gentiluomo, Manuel
%A Katzke, Verena
%A Kaaks, Rudolf
%A Tjonneland, Anne
%A Severi, Gianluca
%A Perduca, Vittorio
%A Boutron-Ruault, Marie-Christine
%A Weiderpass, Elisabete
%A Ferrari, Pietro
%A Johnson, Theron Scot
%A Schulze, Matthias B
%A Bergmann, Manuela
%A Trichopoulou, Antonia
%A Karakatsani, Anna
%A La Vecchia, Carlo
%A Palli, Domenico
%A Grioni, Sara
%A Panico, Salvatore
%A Tumino, Rosario
%A Sacerdote, Carlotta
%A Bueno-de-Mesquita, Bas
%A Vermeulen, Roel
%A Sandanger, Torkjel M
%A Quirós, J Ramón
%A Rodríguez-Barranco, Miguel
%A Amiano, Pilar
%A Colorado-Yohar, Sandra
%A Ardanaz, Eva
%A Sund, Malin
%A Khaw, Kay-Tee
%A Wareham, Nicholas J
%A Schmidt, Julie A
%A Jakszyn, Paula
%A Morelli, Luca
%A Canzian, Federico
%A Campa, Daniele
%T Mitochondrial DNA copy number variation and pancreatic cancer risk in the prospective EPIC cohort.
%J Cancer epidemiology, biomarkers & prevention
%V 29
%N 3
%@ 1538-7755
%C Philadelphia, Pa.
%I AACR
%M DKFZ-2020-00194
%P 681-686
%D 2020
%Z 2020 Mar;29(3):681-686 / #EA:C055#LA:C055#
%X Mitochondrial DNA (mtDNA) copy number in peripheral blood has been found to be associated with risk of developing several cancers. However, data on pancreatic ductal adenocarcinoma (PDAC) are very limited.To further our knowledge on this topic we measured relative mtDNA copy number by a quantitative real-time PCR assay in peripheral leukocyte samples of 476 PDAC cases and 357 controls nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.We observed lower mtDNA copy number with advancing age (p=6.54×10-5) and with a high BMI level (p=0.004) and no association with sex, smoking behavior and alcohol consumption. We found an association between increased mtDNA copy number and decreased risk of developing PDAC with an OR=0.35 (95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31932413
%R 10.1158/1055-9965.EPI-19-0868
%U https://inrepo02.dkfz.de/record/153112