TY  - JOUR
AU  - Gentiluomo, Manuel
AU  - Katzke, Verena
AU  - Kaaks, Rudolf
AU  - Tjonneland, Anne
AU  - Severi, Gianluca
AU  - Perduca, Vittorio
AU  - Boutron-Ruault, Marie-Christine
AU  - Weiderpass, Elisabete
AU  - Ferrari, Pietro
AU  - Johnson, Theron Scot
AU  - Schulze, Matthias B
AU  - Bergmann, Manuela
AU  - Trichopoulou, Antonia
AU  - Karakatsani, Anna
AU  - La Vecchia, Carlo
AU  - Palli, Domenico
AU  - Grioni, Sara
AU  - Panico, Salvatore
AU  - Tumino, Rosario
AU  - Sacerdote, Carlotta
AU  - Bueno-de-Mesquita, Bas
AU  - Vermeulen, Roel
AU  - Sandanger, Torkjel M
AU  - Quirós, J Ramón
AU  - Rodríguez-Barranco, Miguel
AU  - Amiano, Pilar
AU  - Colorado-Yohar, Sandra
AU  - Ardanaz, Eva
AU  - Sund, Malin
AU  - Khaw, Kay-Tee
AU  - Wareham, Nicholas J
AU  - Schmidt, Julie A
AU  - Jakszyn, Paula
AU  - Morelli, Luca
AU  - Canzian, Federico
AU  - Campa, Daniele
TI  - Mitochondrial DNA copy number variation and pancreatic cancer risk in the prospective EPIC cohort.
JO  - Cancer epidemiology, biomarkers & prevention
VL  - 29
IS  - 3
SN  - 1538-7755
CY  - Philadelphia, Pa.
PB  - AACR
M1  - DKFZ-2020-00194
SP  - 681-686
PY  - 2020
N1  - 2020 Mar;29(3):681-686 / #EA:C055#LA:C055#
AB  - Mitochondrial DNA (mtDNA) copy number in peripheral blood has been found to be associated with risk of developing several cancers. However, data on pancreatic ductal adenocarcinoma (PDAC) are very limited.To further our knowledge on this topic we measured relative mtDNA copy number by a quantitative real-time PCR assay in peripheral leukocyte samples of 476 PDAC cases and 357 controls nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.We observed lower mtDNA copy number with advancing age (p=6.54×10-5) and with a high BMI level (p=0.004) and no association with sex, smoking behavior and alcohol consumption. We found an association between increased mtDNA copy number and decreased risk of developing PDAC with an OR=0.35 (95
LB  - PUB:(DE-HGF)16
C6  - pmid:31932413
DO  - DOI:10.1158/1055-9965.EPI-19-0868
UR  - https://inrepo02.dkfz.de/record/153112
ER  -