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@ARTICLE{Gentiluomo:153112,
      author       = {M. Gentiluomo$^*$ and V. Katzke$^*$ and R. Kaaks$^*$ and A.
                      Tjonneland and G. Severi and V. Perduca and M.-C.
                      Boutron-Ruault and E. Weiderpass and P. Ferrari and T. S.
                      Johnson$^*$ and M. B. Schulze and M. Bergmann and A.
                      Trichopoulou and A. Karakatsani and C. La Vecchia and D.
                      Palli and S. Grioni and S. Panico and R. Tumino and C.
                      Sacerdote and B. Bueno-de-Mesquita and R. Vermeulen and T.
                      M. Sandanger and J. R. Quirós and M. Rodríguez-Barranco
                      and P. Amiano and S. Colorado-Yohar and E. Ardanaz and M.
                      Sund and K.-T. Khaw and N. J. Wareham and J. A. Schmidt and
                      P. Jakszyn and L. Morelli and F. Canzian$^*$ and D. Campa},
      title        = {{M}itochondrial {DNA} copy number variation and pancreatic
                      cancer risk in the prospective {EPIC} cohort.},
      journal      = {Cancer epidemiology, biomarkers $\&$ prevention},
      volume       = {29},
      number       = {3},
      issn         = {1538-7755},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2020-00194},
      pages        = {681-686},
      year         = {2020},
      note         = {2020 Mar;29(3):681-686 / #EA:C055#LA:C055#},
      abstract     = {Mitochondrial DNA (mtDNA) copy number in peripheral blood
                      has been found to be associated with risk of developing
                      several cancers. However, data on pancreatic ductal
                      adenocarcinoma (PDAC) are very limited.To further our
                      knowledge on this topic we measured relative mtDNA copy
                      number by a quantitative real-time PCR assay in peripheral
                      leukocyte samples of 476 PDAC cases and 357 controls nested
                      within the European Prospective Investigation into Cancer
                      and Nutrition (EPIC) cohort.We observed lower mtDNA copy
                      number with advancing age (p=6.54×10-5) and with a high BMI
                      level (p=0.004) and no association with sex, smoking
                      behavior and alcohol consumption. We found an association
                      between increased mtDNA copy number and decreased risk of
                      developing PDAC with an OR=0.35 $(95\%$ C.I 0.16-0.79),
                      p=0.01 when comparing the 5th quintile with the 1st using an
                      unconditional logistic regression and OR=0.19 $(95\%$ C.I
                      0.07-0.52), p=0.001 with a conditional analysis. Analyses
                      stratified by BMI showed an association between high mtDNA
                      copy number and decreased risk in the stratum of normal
                      weight, consistent with the main analyses.Our results,
                      suggest a protective effect of a higher number of
                      mitochondria, measured in peripheral blood leukocytes, on
                      PDAC risk.Our findings highlight the importance of
                      understanding the mitochondrial biology in pancreatic
                      cancer.},
      cin          = {C020 / C055},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)C055-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31932413},
      doi          = {10.1158/1055-9965.EPI-19-0868},
      url          = {https://inrepo02.dkfz.de/record/153112},
}