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@ARTICLE{Heath:153120,
      author       = {A. K. Heath and D. C. Muller and P. A. van den Brandt and
                      N. Papadimitriou and E. Critselis and M. Gunter and P.
                      Vineis and E. Weiderpass and G. Fagherazzi and H. Boeing and
                      P. Ferrari and A. Olsen and A. Tjønneland and P. Arveux and
                      M.-C. Boutron-Ruault and F. R. Mancini and T. Kühn$^*$ and
                      R. Turzanski-Fortner$^*$ and M. B. Schulze and A.
                      Karakatsani and P. Thriskos and A. Trichopoulou and G.
                      Masala and P. Contiero and F. Ricceri and S. Panico and B.
                      Bueno-de-Mesquita and M. F. Bakker and C. H. van Gils and K.
                      S. Olsen and G. Skeie and C. Lasheras and A. Agudo and M.
                      Rodríguez-Barranco and M.-J. Sánchez and P. Amiano and
                      M.-D. Chirlaque and A. Barricarte and I. Drake and U.
                      Ericson and I. Johansson and A. Winkvist and T. Key and H.
                      Freisling and M. His and I. Huybrechts and S. Christakoudi
                      and M. Ellingjord-Dale and E. Riboli and K. K. Tsilidis and
                      I. Tzoulaki},
      title        = {{N}utrient-wide association study of 92 foods and nutrients
                      and breast cancer risk.},
      journal      = {Breast cancer research},
      volume       = {22},
      number       = {1},
      issn         = {1465-542X},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DKFZ-2020-00202},
      pages        = {5},
      year         = {2020},
      abstract     = {Several dietary factors have been reported to be associated
                      with risk of breast cancer, but to date, unequivocal
                      evidence only exists for alcohol consumption. We sought to
                      systematically assess the association between intake of 92
                      foods and nutrients and breast cancer risk using a
                      nutrient-wide association study.Using data from 272,098
                      women participating in the European Prospective
                      Investigation into Cancer and Nutrition (EPIC) study, we
                      assessed dietary intake of 92 foods and nutrients estimated
                      by dietary questionnaires. Cox regression was used to
                      quantify the association between each food/nutrient and risk
                      of breast cancer. A false discovery rate (FDR) of 0.05 was
                      used to select the set of foods and nutrients to be
                      replicated in the independent Netherlands Cohort Study
                      (NLCS).Six foods and nutrients were identified as associated
                      with risk of breast cancer in the EPIC study (10,979 cases).
                      Higher intake of alcohol overall was associated with a
                      higher risk of breast cancer (hazard ratio (HR) for a 1 SD
                      increment in intake = 1.05, $95\%$ CI 1.03-1.07), as was
                      beer/cider intake and wine intake (HRs per 1 SD
                      increment = 1.05, $95\%$ CI 1.03-1.06 and 1.04, $95\%$
                      CI 1.02-1.06, respectively), whereas higher intakes of
                      fibre, apple/pear, and carbohydrates were associated with a
                      lower risk of breast cancer (HRs per 1 SD
                      increment = 0.96, $95\%$ CI 0.94-0.98; 0.96, $95\%$ CI
                      0.94-0.99; and 0.96, $95\%$ CI 0.95-0.98, respectively).
                      When evaluated in the NLCS (2368 cases), estimates for each
                      of these foods and nutrients were similar in magnitude and
                      direction, with the exception of beer/cider intake, which
                      was not associated with risk in the NLCS.Our findings
                      confirm a positive association of alcohol consumption and
                      suggest an inverse association of dietary fibre and possibly
                      fruit intake with breast cancer risk.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31931881},
      doi          = {10.1186/s13058-019-1244-7},
      url          = {https://inrepo02.dkfz.de/record/153120},
}