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000153208 1001_ $$0P:(DE-He78)84cedecbe48f90adc2a1453780bdaf33$$aVolz, Lennart$$b0$$eFirst author$$udkfz
000153208 245__ $$aExperimental exploration of a mixed helium/carbon beam for online treatment monitoring in carbon ion beam therapy.
000153208 260__ $$aBristol$$bIOP Publ.$$c2020
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000153208 500__ $$a2020 Feb 28;65(5):055002#EA:E041#LA:E041#PhysicsWorld: TOP 10 Breakthrough of the year 2020:https://physicsworld.com/a/physics-world-announces-its-breakthrough-of-the-year-finalists-for-2020/Here is the link the Physics World review of the paper ranked Top in Medical Physics.https://physicsworld.com/a/mixed-ion-beams-could-enhance-particle-therapy-accuracy/Here is the link to the PMB paperhttps://iopscience.iop.org/article/10.1088/1361-6560/ab6e52
000153208 520__ $$aRecently, it has been proposed that a mixed helium/carbon beam could be used for online monitoring in carbon ion beam therapy. Fully stripped, the two ion species exhibit approximately the same mass/charge ratio and hence could potentially be accelerated simultaneously in a synchrotron to the same energy per nucleon. At the same energy per nucleon, helium ions have about three times the range of carbon ions, which could allow for simultaneous use of the carbon ion beam for treatment and the helium ion beam for imaging. In this work, measurements and simulations of PMMA phantoms as well as anthropomorphic phantoms irradiated sequentially with a helium ion and a carbon ion beam at equal energy per nucleon are presented. The range of the primary helium ion beam and the fragment tail of the carbon ion beam exiting the phantoms were detected using a novel range telescope made of thin plastic scintillator sheets read out by a flat-panel CMOS sensor. A 10:1 carbon to helium mixing ratio is used, generating a helium signal well above the carbon fragment background while adding little to the dose delivered to the patient. The range modulation of a narrow air gap of 1 mm thickness in the PMMA phantom that affects less than a quarter of the particles in a pencil beam were detected, demonstrating the achievable relative sensitivity of the presented method. Using two anthropomorphic pelvis phantoms it is shown that small rotations of the phantom as well as simulated bowel gas movements cause detectable changes in the helium/carbon beam exiting the phantom. The future prospects and limitations of the helium-carbon mixing as well as its technical feasibility are discussed.
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000153208 7001_ $$aKelleter, Laurent$$b1
000153208 7001_ $$aBrons, Stephan$$b2
000153208 7001_ $$0P:(DE-He78)914adea2baeb4f2c6a29637da6500048$$aBurigo, Lucas N$$b3$$udkfz
000153208 7001_ $$00000-0002-5296-7649$$aGraeff, Christian$$b4
000153208 7001_ $$0P:(DE-He78)5c8b2018cd142f209c828d91e37a3e1a$$aNiebuhr, Nina Isabell$$b5$$udkfz
000153208 7001_ $$00000-0002-1094-5038$$aRadogna, Raffaella$$b6
000153208 7001_ $$aScheloske, Stefan$$b7
000153208 7001_ $$aSchömers, Christian$$b8
000153208 7001_ $$aJolly, Simon$$b9
000153208 7001_ $$0P:(DE-He78)102624aca75cfe987c05343d5fdcf2fe$$aSeco, Joao$$b10$$eLast author$$udkfz
000153208 773__ $$0PERI:(DE-600)1473501-5$$a10.1088/1361-6560/ab6e52$$n5$$p055002$$tPhysics in medicine and biology$$v65$$x1361-6560$$y2020
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