%0 Journal Article
%A Pan, Feng
%A Schneider, Daniel
%A Ryschich, Eduard
%A Qian, Baifeng
%A Vollherbst, Dominik F
%A Möhlenbruch, Markus A
%A Jugold, Manfred
%A Eichwald, Viktoria
%A Stenzel, Philipp
%A Pereira, Philippe L
%A Richter, Götz M
%A Kauczor, Hans U
%A Sommer, Christof M
%A Do, Thuy D
%T In Vitro Characterization of a Novel Type of Radiopaque Doxorubicin-Loaded Microsphere.
%J CardioVascular and interventional radiology
%V 43
%N 4
%@ 0174-1551
%C New York, NY
%I Springer65359
%M DKFZ-2020-00256
%P 636-647
%D 2020
%Z 2020 Apr;43(4):636-647
%X To evaluate and compare the material characteristics of a novel type of radiopaque doxorubicin-loaded microsphere (V-100) with radiopaque and non-radiopaque doxorubicin-loaded microspheres.The prototype V-100 featuring inherent radiopacity and three available commercial controls (DC-Bead-LUMI™-70-150, Embozene-Tandem™-100 and DC-Bead™-M1) were analyzed before and after doxorubicin loading (37.5 mg doxorubicin/1 ml microspheres) in suspension with aqua and/or aqua/iodixanol-320. Study goals included inherent radiopacity [e.g., using conventional computed tomography (CT)], doxorubicin loading efficacy, morphology using light and fluorescence microscopy, size distribution using laser diffraction/light scattering, time-in-suspension, rheological properties using rheometer analysis, and microsphere stability observed over a period of 5 days after doxorubicin loading.V-100 showed good inherent radiopacity without adverse imaging artifacts. Under conventional CT, the quantitative radiopacity was as follows: 480.4 ± 2.9HU for V-100, 2432.7 ± 3.2HU for DC-Bead-LUMI™-70-150, 118.1 ± 3.0HU for Embozene-Tandem™-100, and 19.8 ± 1.5HU for DC-Bead™-M1. All of the types of microspheres showed a similar loading efficiency (> 98
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31965224
%R 10.1007/s00270-020-02407-7
%U https://inrepo02.dkfz.de/record/153216