TY  - JOUR
AU  - Pan, Feng
AU  - Schneider, Daniel
AU  - Ryschich, Eduard
AU  - Qian, Baifeng
AU  - Vollherbst, Dominik F
AU  - Möhlenbruch, Markus A
AU  - Jugold, Manfred
AU  - Eichwald, Viktoria
AU  - Stenzel, Philipp
AU  - Pereira, Philippe L
AU  - Richter, Götz M
AU  - Kauczor, Hans U
AU  - Sommer, Christof M
AU  - Do, Thuy D
TI  - In Vitro Characterization of a Novel Type of Radiopaque Doxorubicin-Loaded Microsphere.
JO  - CardioVascular and interventional radiology
VL  - 43
IS  - 4
SN  - 0174-1551
CY  - New York, NY
PB  - Springer65359
M1  - DKFZ-2020-00256
SP  - 636-647
PY  - 2020
N1  - 2020 Apr;43(4):636-647
AB  - To evaluate and compare the material characteristics of a novel type of radiopaque doxorubicin-loaded microsphere (V-100) with radiopaque and non-radiopaque doxorubicin-loaded microspheres.The prototype V-100 featuring inherent radiopacity and three available commercial controls (DC-Bead-LUMI™-70-150, Embozene-Tandem™-100 and DC-Bead™-M1) were analyzed before and after doxorubicin loading (37.5 mg doxorubicin/1 ml microspheres) in suspension with aqua and/or aqua/iodixanol-320. Study goals included inherent radiopacity [e.g., using conventional computed tomography (CT)], doxorubicin loading efficacy, morphology using light and fluorescence microscopy, size distribution using laser diffraction/light scattering, time-in-suspension, rheological properties using rheometer analysis, and microsphere stability observed over a period of 5 days after doxorubicin loading.V-100 showed good inherent radiopacity without adverse imaging artifacts. Under conventional CT, the quantitative radiopacity was as follows: 480.4 ± 2.9HU for V-100, 2432.7 ± 3.2HU for DC-Bead-LUMI™-70-150, 118.1 ± 3.0HU for Embozene-Tandem™-100, and 19.8 ± 1.5HU for DC-Bead™-M1. All of the types of microspheres showed a similar loading efficiency (> 98
LB  - PUB:(DE-HGF)16
C6  - pmid:31965224
DO  - DOI:10.1007/s00270-020-02407-7
UR  - https://inrepo02.dkfz.de/record/153216
ER  -