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@ARTICLE{Pan:153216,
      author       = {F. Pan and D. Schneider and E. Ryschich and B. Qian and D.
                      F. Vollherbst and M. A. Möhlenbruch and M. Jugold$^*$ and
                      V. Eichwald$^*$ and P. Stenzel and P. L. Pereira and G. M.
                      Richter and H. U. Kauczor and C. M. Sommer and T. D. Do},
      title        = {{I}n {V}itro {C}haracterization of a {N}ovel {T}ype of
                      {R}adiopaque {D}oxorubicin-{L}oaded {M}icrosphere.},
      journal      = {CardioVascular and interventional radiology},
      volume       = {43},
      number       = {4},
      issn         = {0174-1551},
      address      = {New York, NY},
      publisher    = {Springer65359},
      reportid     = {DKFZ-2020-00256},
      pages        = {636-647},
      year         = {2020},
      note         = {2020 Apr;43(4):636-647},
      abstract     = {To evaluate and compare the material characteristics of a
                      novel type of radiopaque doxorubicin-loaded microsphere
                      (V-100) with radiopaque and non-radiopaque
                      doxorubicin-loaded microspheres.The prototype V-100
                      featuring inherent radiopacity and three available
                      commercial controls (DC-Bead-LUMI™-70-150,
                      Embozene-Tandem™-100 and DC-Bead™-M1) were analyzed
                      before and after doxorubicin loading (37.5 mg
                      doxorubicin/1 ml microspheres) in suspension with aqua
                      and/or aqua/iodixanol-320. Study goals included inherent
                      radiopacity [e.g., using conventional computed tomography
                      (CT)], doxorubicin loading efficacy, morphology using light
                      and fluorescence microscopy, size distribution using laser
                      diffraction/light scattering, time-in-suspension,
                      rheological properties using rheometer analysis, and
                      microsphere stability observed over a period of 5 days
                      after doxorubicin loading.V-100 showed good inherent
                      radiopacity without adverse imaging artifacts. Under
                      conventional CT, the quantitative radiopacity was as
                      follows: 480.4 ± 2.9HU for V-100, 2432.7 ± 3.2HU
                      for DC-Bead-LUMI™-70-150, 118.1 ± 3.0HU for
                      Embozene-Tandem™-100, and 19.8 ± 1.5HU for
                      DC-Bead™-M1. All of the types of microspheres showed a
                      similar loading efficiency $(> 98\%)$ after 24 h;
                      however, there were slower doxorubicin loading velocities
                      for the radiopaque microspheres. The doxorubicin-loaded
                      V-100 and Embozene-Tandem™-100 showed typical narrow-sized
                      distributions. In aqua/iodixanol-320 suspension,
                      doxorubicin-loaded V-100 showed the best suspension features
                      and ideal deformability and elasticity characteristics.
                      Similar to other microspheres, doxorubicin-loaded V-100 was
                      very stable and storable for at least 5 days.V-100 is a
                      promising novel type of radiopaque doxorubicin-loaded
                      microsphere. Compared with the controls, V-100 shows good
                      inherent radiopacity without adverse imaging artifacts and
                      with comparable doxorubicin loading efficacy. Further
                      advantages of V-100 include narrow-sized distribution and
                      excellent suspension, rheology, and stability features.},
      cin          = {W240},
      ddc          = {610},
      cid          = {I:(DE-He78)W240-20160331},
      pnm          = {319H - Addenda (POF3-319H)},
      pid          = {G:(DE-HGF)POF3-319H},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31965224},
      doi          = {10.1007/s00270-020-02407-7},
      url          = {https://inrepo02.dkfz.de/record/153216},
}