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@ARTICLE{Feller:153220,
      author       = {A. Feller and K. L. Matthes and A. Bordoni and C. Bouchardy
                      and J.-L. Bulliard and C. Herrmann and I. Konzelmann and M.
                      Maspoli and M. Mousavi and S. Rohrmann and K. Staehelin and
                      V. Arndt$^*$ and K. Staehelin and C. Bouchardy and M.
                      Mousavi and J. L. Bulliard and M. Maspoli and M. Mousavi and
                      A. Bordoni and I. Konzelmann and R. Blanc-Moya and S.
                      Rohrmann},
      collaboration = {N. W. Group},
      title        = {{T}he relative risk of second primary cancers in
                      {S}witzerland: a population-based retrospective cohort
                      study.},
      journal      = {BMC cancer},
      volume       = {20},
      number       = {1},
      issn         = {1471-2407},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2020-00260},
      pages        = {51},
      year         = {2020},
      abstract     = {More people than ever before are currently living with a
                      diagnosis of cancer and the number of people concerned is
                      likely to continue to rise. Cancer survivors are at risk of
                      developing a second primary cancer (SPC). This study aims to
                      investigate the risk of SPC in Switzerland.The study cohort
                      included all patients with a first primary cancer recorded
                      in 9 Swiss population-based cancer registries 1981-2009 who
                      had a minimum survival of 6 months, and a potential
                      follow-up until the end of 2014. We calculated standardized
                      incidence ratios (SIR) to estimate relative risks (RR) of
                      SPC in cancer survivors compared with the cancer risk of the
                      general population. SIR were stratified by type of first
                      cancer, sex, age and period of first diagnosis, survival
                      period and site of SPC.A total of 33,793 SPC were observed
                      in 310,113 cancer patients. Both male (SIR 1.18, $95\%CI$
                      1.16-1.19) and female (SIR 1.20, $95\%CI$ 1.18-1.22) cancer
                      survivors had an elevated risk of developing a SPC. Risk
                      estimates varied substantially according to type of first
                      cancer and were highest in patients initially diagnosed with
                      cancer of the oral cavity and pharynx, Hodgkin lymphoma,
                      laryngeal, oesophageal, or lung cancer. Age-stratified
                      analyses revealed a tendency towards higher RR in patients
                      first diagnosed at younger ages. Stratified by survival
                      period, risk estimates showed a rising trend with increasing
                      time from the initial diagnosis. We observed strong
                      associations between particular types of first and SPC, i.e.
                      cancer types sharing common risk factors such as smoking or
                      alcohol consumption (e.g. repeated cancer of the oral cavity
                      and pharynx (SIRmales 20.12, $95\%CI$ 17.91-22.33;
                      SIRfemales 37.87, $95\%CI$ 30.27-45.48).Swiss cancer
                      survivors have an increased risk of developing a SPC
                      compared to the general population, particularly patients
                      first diagnosed before age 50 and those surviving more than
                      10 years. Cancer patients should remain under continued
                      surveillance not only for recurrent cancers but also for new
                      cancers. Some first and SPCs share lifestyle associated risk
                      factors making it important to promote healthier lifestyles
                      in both the general population and cancer survivors.},
      cin          = {C071},
      ddc          = {610},
      cid          = {I:(DE-He78)C071-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31964352},
      doi          = {10.1186/s12885-019-6452-0},
      url          = {https://inrepo02.dkfz.de/record/153220},
}