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@ARTICLE{Riegger:153221,
      author       = {J. Riegger and M. Rehm and G. Büchele and H. Brenner$^*$
                      and K.-P. Günther and D. Rothenbacher and R. E. Brenner},
      title        = {{S}erum {C}artilage {O}ligomeric {M}atrix {P}rotein in
                      {L}ate-{S}tage {O}steoarthritis: {A}ssociation with
                      {C}linical {F}eatures, {R}enal {F}unction, and
                      {C}ardiovascular {B}iomarkers.},
      journal      = {Journal of Clinical Medicine},
      volume       = {9},
      number       = {1},
      issn         = {2077-0383},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2020-00261},
      pages        = {268},
      year         = {2020},
      abstract     = {This study aimed to assess associations between serum
                      cartilage oligomeric matrix protein (sCOMP) and phenotypic
                      characteristics in late-stage hip and knee Osteoarthritis
                      (OA) as well as its correlation with further serum markers
                      of possible comorbidities in the Ulm Osteoarthritis Study.
                      Moreover, the prognostic relevance of preoperative sCOMP
                      concentrations for short-term functionality and pain
                      outcomes after hip or knee joint replacement was explored.
                      Preoperative serum samples and detailed information about
                      the health status (i.e., WOMAC scores, Hannover
                      Functionality Status (FFbH)) of 754 OA patients undergoing
                      total joint replacement were included. Spearman
                      rank-correlation coefficients and multiple linear regression
                      models were used to evaluate the relationships between
                      sCOMP, other serum markers, and health outcomes. There was a
                      significant positive association between sCOMP and markers
                      of renal (cystatin C, creatinine, and eGFR) and cardiac
                      (e.g., NT-proBNP) impairment. Since renal failure might
                      cause accumulation of sCOMP, additional adjustment with eGFR
                      was performed. Preoperative sCOMP levels in knee OA but not
                      hip OA patients were positively associated with FFbH, WOMAC
                      function sub-scale and total WOMAC scale as well as the
                      post-operative WOMAC stiffness sub-scale six months after
                      surgery. Our data clearly demonstrate an association between
                      sCOMP and renal function as well as other confounding
                      factors, which should be considered in future biomarker
                      studies.},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {323 - Metabolic Dysfunction as Risk Factor (POF3-323)},
      pid          = {G:(DE-HGF)POF3-323},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31963737},
      doi          = {10.3390/jcm9010268},
      url          = {https://inrepo02.dkfz.de/record/153221},
}