% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Fresnais:153231,
      author       = {M. Fresnais$^*$ and A. Muck and M. Majewsky and B.
                      Statz$^*$ and S. Krausert$^*$ and J. Benzel and D. Castel
                      and L. Le Dret and S. Pfister$^*$ and W. E. Haefeli and J.
                      Burhenne and R. Longuespée},
      title        = {{R}apid and {S}ensitive {D}rug {Q}uantification in {T}issue
                      {S}ections {U}sing {M}atrix {A}ssisted {L}aser {D}esorption
                      {I}onization-{I}on {M}obility-{M}ass {S}pectrometry
                      {P}rofiling.},
      journal      = {Journal of the American Society for Mass Spectrometry},
      volume       = {31},
      number       = {3},
      issn         = {1044-0305},
      address      = {New York [u.a.]},
      publisher    = {Springer},
      reportid     = {DKFZ-2020-00264},
      pages        = {742-751},
      year         = {2020},
      note         = {2020 Mar 4;31(3):742-751#EA:B062#},
      abstract     = {Ion mobility spectrometry (IMS) represents a considerable
                      asset for analytics of complex samples as it allows for
                      rapid mass spectrometric separation of compounds. IMS is
                      even more useful for the separation of isobaric compounds
                      when classical separation methods such as liquid
                      chromatography or electrophoresis cannot be used, e.g.,
                      during matrix-assisted laser desorption/ionization (MALDI)
                      analyses of biological surfaces. In the present study, we
                      proved the usefulness of IMS for pharmacological
                      applications of MALDI analyses on tissue sections. To
                      illustrate our proof-of-concept, we used the anthelmintic
                      drug mebendazole (MBZ) as a model. Using this exemplary
                      drug, we demonstrated the possibility of using ion mobility
                      to discriminate a drug in tissues from the biological
                      background that masked its signal at low concentrations. In
                      this proof-of-concept, the IMS mode together with the use of
                      a profiling approach for sample preparation enabled
                      quantification of the model drug MBZ from tissue sections in
                      the concentration range 5 to 5,000 ng/g and with a limit of
                      detection of 1 ng/g of tissue, within 2 h. This study
                      highlights the importance of IMS as a separation method for
                      on-surface quantification of drugs in tissue sections.},
      cin          = {B062 / HD01},
      ddc          = {530},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31971791},
      doi          = { 10.1021/jasms.0c00005 },
      url          = {https://inrepo02.dkfz.de/record/153231},
}