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@ARTICLE{Anusruti:153245,
      author       = {A. Anusruti$^*$ and E. H. J. M. Jansen and X. Gào$^*$ and
                      Y. Xuan$^*$ and H. Brenner$^*$ and B. Schöttker$^*$},
      title        = {{L}ongitudinal {A}ssociations of {B}ody {M}ass {I}ndex,
                      {W}aist {C}ircumference, and {W}aist-to-{H}ip {R}atio with
                      {B}iomarkers of {O}xidative {S}tress in {O}lder {A}dults:
                      {R}esults of a {L}arge {C}ohort {S}tudy.},
      journal      = {Obesity facts},
      volume       = {13},
      number       = {1},
      issn         = {1662-4025},
      address      = {Sydney},
      publisher    = {Karger},
      reportid     = {DKFZ-2020-00278},
      pages        = {66-76},
      year         = {2020},
      note         = {EA:C070LA:C0702020;13(1):66-76#EA:C070#LA:C070#},
      abstract     = {In the literature, obesity is discussed as a determinant of
                      high oxidative stress (OS). Hence, prevention or reduction
                      of obesity could prevent high OS and subsequently serve as a
                      target for 'healthy aging.'Diacron's reactive oxygen
                      metabolites test (D-ROM) and total thiol levels (TTL), a
                      marker of antioxidant defense capacity, were measured in
                      1,734 participants of a population-based cohort study of
                      older adults (age range: 57-83 years) at 2 time points 3
                      years apart. The longitudinal associations of body mass
                      index, waist-to-hip ratio, and waist circumference with
                      D-ROM and TTL were assessed with multivariable adjusted
                      generalized linear models. Dose-response analyses were
                      conducted with restricted cubic splines.D-ROM was not
                      significantly associated with any of the weight measures. On
                      the contrary, TTL showed statistically significant, inverse
                      linear associations with all weight measures.A healthy body
                      weight seems to be highly relevant for the antioxidative
                      defense capacity of human beings. In contrast, D-ROM levels
                      were independent of the study participant's weight. Clinical
                      trials are needed to corroborate if loss of weight by obese
                      individuals can effectively increase TTL and subsequently
                      also life expectancy.},
      cin          = {C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31986512},
      doi          = {10.1159/000504711 },
      url          = {https://inrepo02.dkfz.de/record/153245},
}