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@ARTICLE{Kyei:153249,
      author       = {N. N. A. Kyei and D. Boakye$^*$ and S. Gabrysch},
      title        = {{M}aternal mycotoxin exposure and adverse pregnancy
                      outcomes: a systematic review},
      journal      = {Mycotoxin research},
      volume       = {36},
      number       = {2},
      issn         = {1867-1632},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2020-00282},
      pages        = {243-255},
      year         = {2020},
      note         = {2020 May;36(2):243-255},
      abstract     = {Mycotoxin exposure from food occurs globally but is more
                      common in hot humid environments, especially in low-income
                      settings, and might affect pregnancy outcomes. This study
                      aimed to synthesize the evidence from epidemiological
                      studies on the relationship between maternal or fetal
                      exposure to different mycotoxins and the occurrence of
                      adverse pregnancy outcomes. Multiple databases were
                      systematically searched up to December 2018 to identify
                      studies that assessed the association between mycotoxin
                      exposure in pregnant women or fetuses and at least one
                      pregnancy outcome. Studies were appraised and results were
                      synthesized using standard methods for conducting systematic
                      reviews. This review identified and included 17 relevant
                      studies. There is some evidence to suggest that exposure to
                      various Aspergillus mycotoxins (e.g., aflatoxin) during
                      pregnancy may impair intrauterine fetal growth and promote
                      neonatal jaundice. Findings were inconclusive concerning the
                      influence of aflatoxin exposure on perinatal death and
                      preterm birth. Only two studies assessed effects of maternal
                      exposure to Fusarium mycotoxins (e.g., fumonisin) on adverse
                      pregnancy outcomes. These studies found that maternal
                      fumonisin exposure may be associated with hypertensive
                      emergencies in pregnancy and with neural tube defects.
                      Studies using grain farming and weather conditions as a
                      proxy measure for mycotoxin exposure found that such
                      exposure was associated with an increased risk of preterm
                      birth and late-term miscarriage. In conclusion, there is
                      already some evidence to suggest that exposure to mycotoxins
                      during pregnancy may have detrimental effects on pregnancy
                      outcomes. However, given the limited number of studies,
                      especially on effects of Fusarium mycotoxins, more studies
                      are needed for a more comprehensive understanding of the
                      effects of different mycotoxins on maternal and fetal health
                      and to guide public health policies and interventions.},
      subtyp        = {Review Article},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31989413},
      doi          = {10.1007/s12550-019-00384-6},
      url          = {https://inrepo02.dkfz.de/record/153249},
}