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@ARTICLE{Papadimitriou:153516,
      author       = {N. Papadimitriou and N. Dimou and K. K. Tsilidis and B.
                      Banbury and R. M. Martin and S. J. Lewis and N. Kazmi and T.
                      M. Robinson and D. Albanes and K. Aleksandrova and S. I.
                      Berndt and D. Timothy Bishop and H. Brenner$^*$ and D. D.
                      Buchanan and B. Bueno-de-Mesquita and P. T. Campbell and S.
                      Castellví-Bel and A. T. Chan and J. Chang-Claude$^*$ and M.
                      Ellingjord-Dale and J. C. Figueiredo and S. J. Gallinger and
                      G. G. Giles and E. Giovannucci and S. B. Gruber and A. Gsur
                      and J. Hampe and H. Hampel and S. Harlid and T. A. Harrison
                      and M. Hoffmeister$^*$ and J. L. Hopper and L. Hsu and J.
                      María Huerta and J. R. Huyghe and M. A. Jenkins and T. O.
                      Keku and T. Kühn$^*$ and C. La Vecchia and L. Le Marchand
                      and C. I. Li and L. Li and A. Lindblom and N. M. Lindor and
                      B. Lynch and S. D. Markowitz and G. Masala and A. M. May and
                      R. Milne and E. Monninkhof and L. Moreno and V. Moreno and
                      P. A. Newcomb and K. Offit and V. Perduca and P. D. P.
                      Pharoah and E. A. Platz and J. D. Potter and G. Rennert and
                      E. Riboli and M.-J. Sánchez and S. L. Schmit and R. E.
                      Schoen and G. Severi and S. Sieri and M. L. Slattery and M.
                      Song and C. M. Tangen and S. N. Thibodeau and R. C. Travis
                      and A. Trichopoulou and C. M. Ulrich and F. J. B. van
                      Duijnhoven and B. Van Guelpen and P. Vodicka and E. White
                      and A. Wolk and M. O. Woods and A. H. Wu and U. Peters and
                      M. J. Gunter and N. Murphy},
      title        = {{P}hysical activity and risks of breast and colorectal
                      cancer: a {M}endelian randomisation analysis.},
      journal      = {Nature Communications},
      volume       = {11},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2020-00303},
      pages        = {597},
      year         = {2020},
      abstract     = {Physical activity has been associated with lower risks of
                      breast and colorectal cancer in epidemiological studies;
                      however, it is unknown if these associations are causal or
                      confounded. In two-sample Mendelian randomisation analyses,
                      using summary genetic data from the UK Biobank and GWA
                      consortia, we found that a one standard deviation increment
                      in average acceleration was associated with lower risks of
                      breast cancer (odds ratio [OR]: 0.51, $95\%$ confidence
                      interval [CI]: 0.27 to 0.98, P-value = 0.04) and
                      colorectal cancer (OR: 0.66, $95\%$ CI: 0.48 to 0.90,
                      P-value = 0.01). We found similar magnitude inverse
                      associations for estrogen positive (ER+ve) breast cancer and
                      for colon cancer. Our results support a potentially causal
                      relationship between higher physical activity levels and
                      lower risks of breast cancer and colorectal cancer. Based on
                      these data, the promotion of physical activity is probably
                      an effective strategy in the primary prevention of these
                      commonly diagnosed cancers.},
      cin          = {C070 / C120 / HD01 / C020},
      ddc          = {500},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32001714},
      doi          = {10.1038/s41467-020-14389-8},
      url          = {https://inrepo02.dkfz.de/record/153516},
}