%0 Journal Article
%A Paredes-Cisneros, Isabela
%A Karger, Christian P
%A Caprile, Paola
%A Nolte, David
%A Espinoza, Ignacio
%A Gago-Arias, Araceli
%T Simulation of hypoxia PET-tracer uptake in tumours: Dependence of clinical uptake-values on transport parameters and arterial input function.
%J Physica medica
%V 70
%@ 1120-1797
%C Amsterdam
%I Elsevier
%M DKFZ-2020-00307
%P 109 - 117
%D 2020
%Z #EA:E040#
%X Poor radiotherapy outcome is in many cases related to hypoxia, due to the increased radioresistance of hypoxic tumour cells. Positron emission tomography may be used to non-invasively assess the oxygenation status of the tumour using hypoxia-specific radiotracers. Quantification and interpretation of these images remains challenging, since radiotracer binding and oxygen tension are not uniquely related. Computer simulation is a useful tool to improve the understanding of tracer dynamics and its relation to clinical uptake parameters currently used to quantify hypoxia. In this study, a model for simulating oxygen and radiotracer distribution in tumours was implemented to analyse the impact of physiological transport parameters and of the arterial input function (AIF) on: oxygenation histograms, time-activity curves, tracer binding and clinical uptake-values (tissue-to-blood ratio, TBR, and a composed hypoxia-perfusion metric, FHP). Results were obtained for parallel and orthogonal vessel architectures and for vascular fractions (VFs) of 1
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32006939
%R 10.1016/j.ejmp.2020.01.012
%U https://inrepo02.dkfz.de/record/153520