TY  - JOUR
AU  - Paredes-Cisneros, Isabela
AU  - Karger, Christian P
AU  - Caprile, Paola
AU  - Nolte, David
AU  - Espinoza, Ignacio
AU  - Gago-Arias, Araceli
TI  - Simulation of hypoxia PET-tracer uptake in tumours: Dependence of clinical uptake-values on transport parameters and arterial input function.
JO  - Physica medica
VL  - 70
SN  - 1120-1797
CY  - Amsterdam
PB  - Elsevier
M1  - DKFZ-2020-00307
SP  - 109 - 117
PY  - 2020
N1  - #EA:E040#
AB  - Poor radiotherapy outcome is in many cases related to hypoxia, due to the increased radioresistance of hypoxic tumour cells. Positron emission tomography may be used to non-invasively assess the oxygenation status of the tumour using hypoxia-specific radiotracers. Quantification and interpretation of these images remains challenging, since radiotracer binding and oxygen tension are not uniquely related. Computer simulation is a useful tool to improve the understanding of tracer dynamics and its relation to clinical uptake parameters currently used to quantify hypoxia. In this study, a model for simulating oxygen and radiotracer distribution in tumours was implemented to analyse the impact of physiological transport parameters and of the arterial input function (AIF) on: oxygenation histograms, time-activity curves, tracer binding and clinical uptake-values (tissue-to-blood ratio, TBR, and a composed hypoxia-perfusion metric, FHP). Results were obtained for parallel and orthogonal vessel architectures and for vascular fractions (VFs) of 1
LB  - PUB:(DE-HGF)16
C6  - pmid:32006939
DO  - DOI:10.1016/j.ejmp.2020.01.012
UR  - https://inrepo02.dkfz.de/record/153520
ER  -