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000153601 037__ $$aDKFZ-2020-00345
000153601 041__ $$aeng
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000153601 1001_ $$aGerstung, Moritz$$b0
000153601 245__ $$aThe evolutionary history of 2,658 cancers.
000153601 260__ $$aLondon [u.a.]$$bNature Publ. Group52462$$c2020
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000153601 500__ $$asiehe Correction: DKFZ Autoren affiliiert im PCAWG Consortium: https://inrepo02.dkfz.de/record/212474  /  https://doi.org/10.1038/s41586-022-05601-4
000153601 520__ $$aCancer develops through a process of somatic evolution1,2. Sequencing data from a single biopsy represent a snapshot of this process that can reveal the timing of specific genomic aberrations and the changing influence of mutational processes3. Here, by whole-genome sequencing analysis of 2,658 cancers as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA)4, we reconstruct the life history and evolution of mutational processes and driver mutation sequences of 38 types of cancer. Early oncogenesis is characterized by mutations in a constrained set of driver genes, and specific copy number gains, such as trisomy 7 in glioblastoma and isochromosome 17q in medulloblastoma. The mutational spectrum changes significantly throughout tumour evolution in 40% of samples. A nearly fourfold diversification of driver genes and increased genomic instability are features of later stages. Copy number alterations often occur in mitotic crises, and lead to simultaneous gains of chromosomal segments. Timing analyses suggest that driver mutations often precede diagnosis by many years, if not decades. Together, these results determine the evolutionary trajectories of cancer, and highlight opportunities for early cancer detection.
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000153601 7001_ $$aJolly, Clemency$$b1
000153601 7001_ $$aLeshchiner, Ignaty$$b2
000153601 7001_ $$aDentro, Stefan$$b3
000153601 7001_ $$aGonzalez, Santiago$$b4
000153601 7001_ $$aRosebrock, Daniel$$b5
000153601 7001_ $$aMitchell, Thomas J$$b6
000153601 7001_ $$aRubanova, Yulia$$b7
000153601 7001_ $$aAnur, Pavana$$b8
000153601 7001_ $$aYu, Kaixian$$b9
000153601 7001_ $$aTarabichi, Maxime$$b10
000153601 7001_ $$aDeshwar, Amit$$b11
000153601 7001_ $$aWintersinger, Jeff$$b12
000153601 7001_ $$0P:(DE-He78)e053817bc90becc8a8dd8250e677e773$$aKleinheinz, Kortine$$b13
000153601 7001_ $$aVázquez-García, Ignacio$$b14
000153601 7001_ $$aHaase, Kerstin$$b15
000153601 7001_ $$aJerman, Lara$$b16
000153601 7001_ $$aSengupta, Subhajit$$b17
000153601 7001_ $$aMacintyre, Geoff$$b18
000153601 7001_ $$aMalikic, Salem$$b19
000153601 7001_ $$aDonmez, Nilgun$$b20
000153601 7001_ $$aLivitz, Dimitri G$$b21
000153601 7001_ $$aCmero, Marek$$b22
000153601 7001_ $$aDemeulemeester, Jonas$$b23
000153601 7001_ $$aSchumacher, Steven$$b24
000153601 7001_ $$aFan, Yu$$b25
000153601 7001_ $$aYao, Xiaotong$$b26
000153601 7001_ $$aLee, Juhee$$b27
000153601 7001_ $$0P:(DE-He78)f2a782242acf94a3114d75c45dc75b37$$aSchlesner, Matthias$$b28
000153601 7001_ $$aBoutros, Paul C$$b29
000153601 7001_ $$aBowtell, David D$$b30
000153601 7001_ $$aZhu, Hongtu$$b31
000153601 7001_ $$aGetz, Gad$$b32
000153601 7001_ $$aImielinski, Marcin$$b33
000153601 7001_ $$aBeroukhim, Rameen$$b34
000153601 7001_ $$aSahinalp, S Cenk$$b35
000153601 7001_ $$aJi, Yuan$$b36
000153601 7001_ $$aPeifer, Martin$$b37
000153601 7001_ $$aMarkowetz, Florian$$b38
000153601 7001_ $$aMustonen, Ville$$b39
000153601 7001_ $$aYuan, Ke$$b40
000153601 7001_ $$aWang, Wenyi$$b41
000153601 7001_ $$aMorris, Quaid D$$b42
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000153601 7001_ $$aSpellman, Paul T$$b44
000153601 7001_ $$aWedge, David C$$b45
000153601 7001_ $$aVan Loo, Peter$$b46
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