TY  - JOUR
AU  - Gerstung, Moritz
AU  - Jolly, Clemency
AU  - Leshchiner, Ignaty
AU  - Dentro, Stefan
AU  - Gonzalez, Santiago
AU  - Rosebrock, Daniel
AU  - Mitchell, Thomas J
AU  - Rubanova, Yulia
AU  - Anur, Pavana
AU  - Yu, Kaixian
AU  - Tarabichi, Maxime
AU  - Deshwar, Amit
AU  - Wintersinger, Jeff
AU  - Kleinheinz, Kortine
AU  - Vázquez-García, Ignacio
AU  - Haase, Kerstin
AU  - Jerman, Lara
AU  - Sengupta, Subhajit
AU  - Macintyre, Geoff
AU  - Malikic, Salem
AU  - Donmez, Nilgun
AU  - Livitz, Dimitri G
AU  - Cmero, Marek
AU  - Demeulemeester, Jonas
AU  - Schumacher, Steven
AU  - Fan, Yu
AU  - Yao, Xiaotong
AU  - Lee, Juhee
AU  - Schlesner, Matthias
AU  - Boutros, Paul C
AU  - Bowtell, David D
AU  - Zhu, Hongtu
AU  - Getz, Gad
AU  - Imielinski, Marcin
AU  - Beroukhim, Rameen
AU  - Sahinalp, S Cenk
AU  - Ji, Yuan
AU  - Peifer, Martin
AU  - Markowetz, Florian
AU  - Mustonen, Ville
AU  - Yuan, Ke
AU  - Wang, Wenyi
AU  - Morris, Quaid D
AU  - PCAWGEvolution&HeterogeneityWorkingGroup
AU  - Spellman, Paul T
AU  - Wedge, David C
AU  - Van Loo, Peter
AU  - PCAWGConsortium
TI  - The evolutionary history of 2,658 cancers.
JO  - Nature 
VL  - 578
IS  - 7793
SN  - 1476-4687
CY  - London [u.a.]
PB  - Nature Publ. Group52462
M1  - DKFZ-2020-00345
SP  - 122 - 128
PY  - 2020
N1  - siehe Correction: DKFZ Autoren affiliiert im PCAWG Consortium: https://inrepo02.dkfz.de/record/212474  /  https://doi.org/10.1038/s41586-022-05601-4
AB  - Cancer develops through a process of somatic evolution1,2. Sequencing data from a single biopsy represent a snapshot of this process that can reveal the timing of specific genomic aberrations and the changing influence of mutational processes3. Here, by whole-genome sequencing analysis of 2,658 cancers as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA)4, we reconstruct the life history and evolution of mutational processes and driver mutation sequences of 38 types of cancer. Early oncogenesis is characterized by mutations in a constrained set of driver genes, and specific copy number gains, such as trisomy 7 in glioblastoma and isochromosome 17q in medulloblastoma. The mutational spectrum changes significantly throughout tumour evolution in 40
LB  - PUB:(DE-HGF)16
C6  - pmid:32025013
DO  - DOI:10.1038/s41586-019-1907-7
UR  - https://inrepo02.dkfz.de/record/153601
ER  -