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@ARTICLE{Gerstung:153601,
      author       = {M. Gerstung and C. Jolly and I. Leshchiner and S. Dentro
                      and S. Gonzalez and D. Rosebrock and T. J. Mitchell and Y.
                      Rubanova and P. Anur and K. Yu and M. Tarabichi and A.
                      Deshwar and J. Wintersinger and K. Kleinheinz$^*$ and I.
                      Vázquez-García and K. Haase and L. Jerman and S. Sengupta
                      and G. Macintyre and S. Malikic and N. Donmez and D. G.
                      Livitz and M. Cmero and J. Demeulemeester and S. Schumacher
                      and Y. Fan and X. Yao and J. Lee and M. Schlesner$^*$ and P.
                      C. Boutros and D. D. Bowtell and H. Zhu and G. Getz and M.
                      Imielinski and R. Beroukhim and S. C. Sahinalp and Y. Ji and
                      M. Peifer and F. Markowetz and V. Mustonen and K. Yuan and
                      W. Wang and Q. D. Morris and
                      PCAWGEvolution\&HeterogeneityWorkingGroup and P. T. Spellman
                      and D. C. Wedge and P. Van Loo and PCAWGConsortium},
      title        = {{T}he evolutionary history of 2,658 cancers.},
      journal      = {Nature},
      volume       = {578},
      number       = {7793},
      issn         = {1476-4687},
      address      = {London [u.a.]},
      publisher    = {Nature Publ. Group52462},
      reportid     = {DKFZ-2020-00345},
      pages        = {122 - 128},
      year         = {2020},
      note         = {siehe Correction: DKFZ Autoren affiliiert im PCAWG
                      Consortium: https://inrepo02.dkfz.de/record/212474 /
                      https://doi.org/10.1038/s41586-022-05601-4},
      abstract     = {Cancer develops through a process of somatic evolution1,2.
                      Sequencing data from a single biopsy represent a snapshot of
                      this process that can reveal the timing of specific genomic
                      aberrations and the changing influence of mutational
                      processes3. Here, by whole-genome sequencing analysis of
                      2,658 cancers as part of the Pan-Cancer Analysis of Whole
                      Genomes (PCAWG) Consortium of the International Cancer
                      Genome Consortium (ICGC) and The Cancer Genome Atlas
                      (TCGA)4, we reconstruct the life history and evolution of
                      mutational processes and driver mutation sequences of 38
                      types of cancer. Early oncogenesis is characterized by
                      mutations in a constrained set of driver genes, and specific
                      copy number gains, such as trisomy 7 in glioblastoma and
                      isochromosome 17q in medulloblastoma. The mutational
                      spectrum changes significantly throughout tumour evolution
                      in $40\%$ of samples. A nearly fourfold diversification of
                      driver genes and increased genomic instability are features
                      of later stages. Copy number alterations often occur in
                      mitotic crises, and lead to simultaneous gains of
                      chromosomal segments. Timing analyses suggest that driver
                      mutations often precede diagnosis by many years, if not
                      decades. Together, these results determine the evolutionary
                      trajectories of cancer, and highlight opportunities for
                      early cancer detection.},
      cin          = {B080 / B240 / B370 / B330 / HD01 / B060 / B360 / BE01 /
                      B062 / B066 / B063 / W190 / B260 / W610 / B087},
      ddc          = {500},
      cid          = {I:(DE-He78)B080-20160331 / I:(DE-He78)B240-20160331 /
                      I:(DE-He78)B370-20160331 / I:(DE-He78)B330-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)B060-20160331 /
                      I:(DE-He78)B360-20160331 / I:(DE-He78)BE01-20160331 /
                      I:(DE-He78)B062-20160331 / I:(DE-He78)B066-20160331 /
                      I:(DE-He78)B063-20160331 / I:(DE-He78)W190-20160331 /
                      I:(DE-He78)B260-20160331 / I:(DE-He78)W610-20160331 /
                      I:(DE-He78)B087-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32025013},
      doi          = {10.1038/s41586-019-1907-7},
      url          = {https://inrepo02.dkfz.de/record/153601},
}