guest ::
| Home > Publications database > The evolutionary history of 2,658 cancers. > print |
| 001 | 153601 | ||
| 005 | 20240320151820.0 | ||
| 024 | 7 | _ | |a 10.1038/s41586-019-1907-7 |2 doi |
| 024 | 7 | _ | |a pmid:32025013 |2 pmid |
| 024 | 7 | _ | |a 0028-0836 |2 ISSN |
| 024 | 7 | _ | |a 1476-4687 |2 ISSN |
| 024 | 7 | _ | |a altmetric:75075728 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2020-00345 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 500 |
| 100 | 1 | _ | |a Gerstung, Moritz |b 0 |
| 245 | _ | _ | |a The evolutionary history of 2,658 cancers. |
| 260 | _ | _ | |a London [u.a.] |c 2020 |b Nature Publ. Group52462 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1710944072_4145 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a siehe Correction: DKFZ Autoren affiliiert im PCAWG Consortium: https://inrepo02.dkfz.de/record/212474 / https://doi.org/10.1038/s41586-022-05601-4 |
| 520 | _ | _ | |a Cancer develops through a process of somatic evolution1,2. Sequencing data from a single biopsy represent a snapshot of this process that can reveal the timing of specific genomic aberrations and the changing influence of mutational processes3. Here, by whole-genome sequencing analysis of 2,658 cancers as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA)4, we reconstruct the life history and evolution of mutational processes and driver mutation sequences of 38 types of cancer. Early oncogenesis is characterized by mutations in a constrained set of driver genes, and specific copy number gains, such as trisomy 7 in glioblastoma and isochromosome 17q in medulloblastoma. The mutational spectrum changes significantly throughout tumour evolution in 40% of samples. A nearly fourfold diversification of driver genes and increased genomic instability are features of later stages. Copy number alterations often occur in mitotic crises, and lead to simultaneous gains of chromosomal segments. Timing analyses suggest that driver mutations often precede diagnosis by many years, if not decades. Together, these results determine the evolutionary trajectories of cancer, and highlight opportunities for early cancer detection. |
| 536 | _ | _ | |a 312 - Functional and structural genomics (POF3-312) |0 G:(DE-HGF)POF3-312 |c POF3-312 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 700 | 1 | _ | |a Jolly, Clemency |b 1 |
| 700 | 1 | _ | |a Leshchiner, Ignaty |b 2 |
| 700 | 1 | _ | |a Dentro, Stefan |b 3 |
| 700 | 1 | _ | |a Gonzalez, Santiago |b 4 |
| 700 | 1 | _ | |a Rosebrock, Daniel |b 5 |
| 700 | 1 | _ | |a Mitchell, Thomas J |b 6 |
| 700 | 1 | _ | |a Rubanova, Yulia |b 7 |
| 700 | 1 | _ | |a Anur, Pavana |b 8 |
| 700 | 1 | _ | |a Yu, Kaixian |b 9 |
| 700 | 1 | _ | |a Tarabichi, Maxime |b 10 |
| 700 | 1 | _ | |a Deshwar, Amit |b 11 |
| 700 | 1 | _ | |a Wintersinger, Jeff |b 12 |
| 700 | 1 | _ | |a Kleinheinz, Kortine |0 P:(DE-He78)e053817bc90becc8a8dd8250e677e773 |b 13 |
| 700 | 1 | _ | |a Vázquez-García, Ignacio |b 14 |
| 700 | 1 | _ | |a Haase, Kerstin |b 15 |
| 700 | 1 | _ | |a Jerman, Lara |b 16 |
| 700 | 1 | _ | |a Sengupta, Subhajit |b 17 |
| 700 | 1 | _ | |a Macintyre, Geoff |b 18 |
| 700 | 1 | _ | |a Malikic, Salem |b 19 |
| 700 | 1 | _ | |a Donmez, Nilgun |b 20 |
| 700 | 1 | _ | |a Livitz, Dimitri G |b 21 |
| 700 | 1 | _ | |a Cmero, Marek |b 22 |
| 700 | 1 | _ | |a Demeulemeester, Jonas |b 23 |
| 700 | 1 | _ | |a Schumacher, Steven |b 24 |
| 700 | 1 | _ | |a Fan, Yu |b 25 |
| 700 | 1 | _ | |a Yao, Xiaotong |b 26 |
| 700 | 1 | _ | |a Lee, Juhee |b 27 |
| 700 | 1 | _ | |a Schlesner, Matthias |0 P:(DE-He78)f2a782242acf94a3114d75c45dc75b37 |b 28 |
| 700 | 1 | _ | |a Boutros, Paul C |b 29 |
| 700 | 1 | _ | |a Bowtell, David D |b 30 |
| 700 | 1 | _ | |a Zhu, Hongtu |b 31 |
| 700 | 1 | _ | |a Getz, Gad |b 32 |
| 700 | 1 | _ | |a Imielinski, Marcin |b 33 |
| 700 | 1 | _ | |a Beroukhim, Rameen |b 34 |
| 700 | 1 | _ | |a Sahinalp, S Cenk |b 35 |
| 700 | 1 | _ | |a Ji, Yuan |b 36 |
| 700 | 1 | _ | |a Peifer, Martin |b 37 |
| 700 | 1 | _ | |a Markowetz, Florian |b 38 |
| 700 | 1 | _ | |a Mustonen, Ville |b 39 |
| 700 | 1 | _ | |a Yuan, Ke |b 40 |
| 700 | 1 | _ | |a Wang, Wenyi |b 41 |
| 700 | 1 | _ | |a Morris, Quaid D |b 42 |
| 700 | 1 | _ | |a PCAWGEvolution&HeterogeneityWorkingGroup |0 P:(DE-HGF)0 |b 43 |
| 700 | 1 | _ | |a Spellman, Paul T |b 44 |
| 700 | 1 | _ | |a Wedge, David C |b 45 |
| 700 | 1 | _ | |a Van Loo, Peter |b 46 |
| 700 | 1 | _ | |a PCAWGConsortium |0 P:(DE-HGF)0 |b 47 |
| 773 | _ | _ | |a 10.1038/s41586-019-1907-7 |g Vol. 578, no. 7793, p. 122 - 128 |0 PERI:(DE-600)1413423-8 |n 7793 |p 122 - 128 |t Nature |v 578 |y 2020 |x 1476-4687 |
| 909 | C | O | |p VDB |o oai:inrepo02.dkfz.de:153601 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 13 |6 P:(DE-He78)e053817bc90becc8a8dd8250e677e773 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 28 |6 P:(DE-He78)f2a782242acf94a3114d75c45dc75b37 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Krebsforschung |1 G:(DE-HGF)POF3-310 |0 G:(DE-HGF)POF3-312 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Functional and structural genomics |x 0 |
| 914 | 1 | _ | |y 2020 |
| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b NATURE : 2017 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1060 |2 StatID |b Current Contents - Agriculture, Biology and Environmental Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1150 |2 StatID |b Current Contents - Physical, Chemical and Earth Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1040 |2 StatID |b Zoological Record |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a IF >= 40 |0 StatID:(DE-HGF)9940 |2 StatID |b NATURE : 2017 |
| 920 | 1 | _ | |0 I:(DE-He78)B080-20160331 |k B080 |l Theoretische Bioinformatik |x 0 |
| 920 | 1 | _ | |0 I:(DE-He78)B240-20160331 |k B240 |l Bioinformatik und Omics Data Analytics |x 1 |
| 920 | 1 | _ | |0 I:(DE-He78)B370-20160331 |k B370 |l Epigenomik |x 2 |
| 920 | 1 | _ | |0 I:(DE-He78)B330-20160331 |k B330 |l Angewandte Bioinformatik |x 3 |
| 920 | 1 | _ | |0 I:(DE-He78)HD01-20160331 |k HD01 |l DKTK HD zentral |x 4 |
| 920 | 1 | _ | |0 I:(DE-He78)B060-20160331 |k B060 |l B060 Molekulare Genetik |x 5 |
| 920 | 1 | _ | |0 I:(DE-He78)B360-20160331 |k B360 |l Pädiatrische Gliomforschung |x 6 |
| 920 | 1 | _ | |0 I:(DE-He78)BE01-20160331 |k BE01 |l DKTK Koordinierungsstelle Berlin |x 7 |
| 920 | 1 | _ | |0 I:(DE-He78)B062-20160331 |k B062 |l B062 Pädiatrische Neuroonkologie |x 8 |
| 920 | 1 | _ | |0 I:(DE-He78)B066-20160331 |k B066 |l B066 Chromatin-Netzwerke |x 9 |
| 920 | 1 | _ | |0 I:(DE-He78)B063-20160331 |k B063 |l B063 Krebsgenomforschung |x 10 |
| 920 | 1 | _ | |0 I:(DE-He78)W190-20160331 |k W190 |l Hochdurchsatz-Sequenzierung |x 11 |
| 920 | 1 | _ | |0 I:(DE-He78)B260-20160331 |k B260 |l B260 Bioinformatik der Genomik und Systemgenetik |x 12 |
| 920 | 1 | _ | |0 I:(DE-He78)W610-20160331 |k W610 |l Core Facility Omics IT |x 13 |
| 920 | 1 | _ | |0 I:(DE-He78)B087-20160331 |k B087 |l B087 Neuroblastom Genomik |x 14 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)B080-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B240-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B370-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B330-20160331 |
| 980 | _ | _ | |a I:(DE-He78)HD01-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B060-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B360-20160331 |
| 980 | _ | _ | |a I:(DE-He78)BE01-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B062-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B066-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B063-20160331 |
| 980 | _ | _ | |a I:(DE-He78)W190-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B260-20160331 |
| 980 | _ | _ | |a I:(DE-He78)W610-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B087-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|