guest ::
| Home > Publications database > Genomic footprints of activated telomere maintenance mechanisms in cancer. > print |
| Home > Publications database > Genomic footprints of activated telomere maintenance mechanisms in cancer. > print |
| 001 | 153604 | ||
| 005 | 20240229123045.0 | ||
| 024 | 7 | _ | |a 10.1038/s41467-019-13824-9 |2 doi |
| 024 | 7 | _ | |a pmid:32024817 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC7002710 |2 pmc |
| 024 | 7 | _ | |a altmetric:75077399 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2020-00348 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 500 |
| 100 | 1 | _ | |a Sieverling, Lina |0 P:(DE-He78)a82e5b3870b674f83ff39df31c487ac7 |b 0 |e First author |
| 245 | _ | _ | |a Genomic footprints of activated telomere maintenance mechanisms in cancer. |
| 260 | _ | _ | |a [London] |c 2020 |b Nature Publishing Group UK |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1674561651_19776 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a #EA:B330#LA:B330# |
| 520 | _ | _ | |a Cancers require telomere maintenance mechanisms for unlimited replicative potential. They achieve this through TERT activation or alternative telomere lengthening associated with ATRX or DAXX loss. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we dissect whole-genome sequencing data of over 2500 matched tumor-control samples from 36 different tumor types aggregated within the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium to characterize the genomic footprints of these mechanisms. While the telomere content of tumors with ATRX or DAXX mutations (ATRX/DAXXtrunc) is increased, tumors with TERT modifications show a moderate decrease of telomere content. One quarter of all tumor samples contain somatic integrations of telomeric sequences into non-telomeric DNA. This fraction is increased to 80% prevalence in ATRX/DAXXtrunc tumors, which carry an aberrant telomere variant repeat (TVR) distribution as another genomic marker. The latter feature includes enrichment or depletion of the previously undescribed singleton TVRs TTCGGG and TTTGGG, respectively. Our systematic analysis provides new insight into the recurrent genomic alterations associated with telomere maintenance mechanisms in cancer. |
| 536 | _ | _ | |a 312 - Functional and structural genomics (POF3-312) |0 G:(DE-HGF)POF3-312 |c POF3-312 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 700 | 1 | _ | |a Hong, Chen |0 P:(DE-He78)7f6d024a3ef1eee64b6a24c8fcc2a581 |b 1 |
| 700 | 1 | _ | |a Koser, Sandra D |b 2 |
| 700 | 1 | _ | |a Ginsbach, Philip |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Kleinheinz, Kortine |0 P:(DE-He78)e053817bc90becc8a8dd8250e677e773 |b 4 |
| 700 | 1 | _ | |a Hutter, Barbara |0 P:(DE-He78)135e8c8d1dd1b66b8127c3d1e3a9b6a0 |b 5 |
| 700 | 1 | _ | |a Braun, Delia |0 P:(DE-He78)5df998d953f664b5230be9553e48e293 |b 6 |
| 700 | 1 | _ | |a Cortés-Ciriano, Isidro |0 0000-0002-2036-494X |b 7 |
| 700 | 1 | _ | |a Xi, Ruibin |0 0000-0001-7545-7361 |b 8 |
| 700 | 1 | _ | |a Kabbe, Rolf |0 P:(DE-He78)36d0b1aeaf5a81ce289db680388c0adf |b 9 |
| 700 | 1 | _ | |a Park, Peter J |0 0000-0001-9378-960X |b 10 |
| 700 | 1 | _ | |a Eils, Roland |0 P:(DE-He78)78b6aa82148e60b4d91e3a37a6d3d9a0 |b 11 |
| 700 | 1 | _ | |a Schlesner, Matthias |0 P:(DE-He78)f2a782242acf94a3114d75c45dc75b37 |b 12 |
| 700 | 1 | _ | |a Group, PCAWG-Structural Variation Working |b 13 |e Collaboration Author |
| 700 | 1 | _ | |a Brors, Benedikt |0 P:(DE-He78)fc949170377b58098e46141d95c72661 |b 14 |
| 700 | 1 | _ | |a Rippe, Karsten |0 P:(DE-He78)94de5f7413279464b6e738d91dfae1eb |b 15 |
| 700 | 1 | _ | |a Jones, David T W |0 P:(DE-He78)551bb92841f634070997aa168d818492 |b 16 |
| 700 | 1 | _ | |a Feuerbach, Lars |0 P:(DE-He78)75e2afb3ea0812786cc551c10679b67d |b 17 |
| 700 | 1 | _ | |a Consortium, PCAWG |b 18 |e Collaboration Author |
| 700 | 1 | _ | |a Akdemir, Kadir C |b 19 |
| 700 | 1 | _ | |a Alvarez, Eva G |b 20 |
| 700 | 1 | _ | |a Baez-Ortega, Adrian |b 21 |
| 700 | 1 | _ | |a Beroukhim, Rameen |b 22 |
| 700 | 1 | _ | |a Boutros, Paul C |b 23 |
| 700 | 1 | _ | |a Bowtell, David D L |b 24 |
| 700 | 1 | _ | |a Brors, Benedikt |0 P:(DE-He78)fc949170377b58098e46141d95c72661 |b 25 |
| 700 | 1 | _ | |a Burns, Kathleen H |b 26 |
| 700 | 1 | _ | |a Campbell, Peter J |b 27 |
| 700 | 1 | _ | |a Chan, Kin |b 28 |
| 700 | 1 | _ | |a Chen, Ken |b 29 |
| 700 | 1 | _ | |a Cortés-Ciriano, Isidro |b 30 |
| 700 | 1 | _ | |a Dueso-Barroso, Ana |b 31 |
| 700 | 1 | _ | |a Dunford, Andrew J |b 32 |
| 700 | 1 | _ | |a Edwards, Paul A |b 33 |
| 700 | 1 | _ | |a Estivill, Xavier |b 34 |
| 700 | 1 | _ | |a Etemadmoghadam, Dariush |b 35 |
| 700 | 1 | _ | |a Feuerbach, Lars |0 P:(DE-He78)75e2afb3ea0812786cc551c10679b67d |b 36 |e Last author |
| 700 | 1 | _ | |a Fink, J Lynn |b 37 |
| 700 | 1 | _ | |a Frenkel-Morgenstern, Milana |b 38 |
| 700 | 1 | _ | |a Garsed, Dale W |b 39 |
| 700 | 1 | _ | |a Gerstein, Mark |b 40 |
| 700 | 1 | _ | |a Gordenin, Dmitry A |b 41 |
| 700 | 1 | _ | |a Haan, David |b 42 |
| 700 | 1 | _ | |a Haber, James E |b 43 |
| 700 | 1 | _ | |a Hess, Julian M |b 44 |
| 700 | 1 | _ | |a Hutter, Barbara |0 P:(DE-He78)135e8c8d1dd1b66b8127c3d1e3a9b6a0 |b 45 |
| 700 | 1 | _ | |a Imielinski, Marcin |b 46 |
| 700 | 1 | _ | |a Jones, David T W |0 P:(DE-He78)551bb92841f634070997aa168d818492 |b 47 |
| 700 | 1 | _ | |a Ju, Young Seok |b 48 |
| 700 | 1 | _ | |a Kazanov, Marat D |b 49 |
| 700 | 1 | _ | |a Klimczak, Leszek J |b 50 |
| 700 | 1 | _ | |a Koh, Youngil |b 51 |
| 700 | 1 | _ | |a Korbel, Jan O |b 52 |
| 700 | 1 | _ | |a Kumar, Kiran |b 53 |
| 700 | 1 | _ | |a Lee, Eunjung Alice |b 54 |
| 700 | 1 | _ | |a Lee, Jake June-Koo |b 55 |
| 700 | 1 | _ | |a Li, Yilong |b 56 |
| 700 | 1 | _ | |a Lynch, Andy G |b 57 |
| 700 | 1 | _ | |a Macintyre, Geoff |b 58 |
| 700 | 1 | _ | |a Markowetz, Florian |b 59 |
| 700 | 1 | _ | |a Martincorena, Iñigo |b 60 |
| 700 | 1 | _ | |a Martinez-Fundichely, Alexander |b 61 |
| 700 | 1 | _ | |a Meyerson, Matthew |b 62 |
| 700 | 1 | _ | |a Miyano, Satoru |b 63 |
| 700 | 1 | _ | |a Nakagawa, Hidewaki |b 64 |
| 700 | 1 | _ | |a Navarro, Fabio C P |b 65 |
| 700 | 1 | _ | |a Ossowski, Stephan |b 66 |
| 700 | 1 | _ | |a Park, Peter J |b 67 |
| 700 | 1 | _ | |a Pearson, John V |b 68 |
| 700 | 1 | _ | |a Puiggròs, Montserrat |b 69 |
| 700 | 1 | _ | |a Rippe, Karsten |0 P:(DE-He78)94de5f7413279464b6e738d91dfae1eb |b 70 |
| 700 | 1 | _ | |a Roberts, Nicola D |b 71 |
| 700 | 1 | _ | |a Roberts, Steven A |b 72 |
| 700 | 1 | _ | |a Rodriguez-Martin, Bernardo |b 73 |
| 700 | 1 | _ | |a Schumacher, Steven E |b 74 |
| 700 | 1 | _ | |a Scully, Ralph |b 75 |
| 700 | 1 | _ | |a Shackleton, Mark |b 76 |
| 700 | 1 | _ | |a Sidiropoulos, Nikos |b 77 |
| 700 | 1 | _ | |a Sieverling, Lina |0 P:(DE-He78)a82e5b3870b674f83ff39df31c487ac7 |b 78 |
| 700 | 1 | _ | |a Stewart, Chip |b 79 |
| 700 | 1 | _ | |a Sültmann, Holger |0 P:(DE-He78)7483734fd8ab316391aa604c95f0e98a |b 80 |u dkfz |
| 700 | 1 | _ | |a Torrents, David |b 81 |
| 700 | 1 | _ | |a Tubio, Jose M C |b 82 |
| 700 | 1 | _ | |a Villasante, Izar |b 83 |
| 700 | 1 | _ | |a Waddell, Nicola |b 84 |
| 700 | 1 | _ | |a Wala, Jeremiah A |b 85 |
| 700 | 1 | _ | |a Weischenfeldt, Joachim |b 86 |
| 700 | 1 | _ | |a Yang, Lixing |b 87 |
| 700 | 1 | _ | |a Yao, Xiaotong |b 88 |
| 700 | 1 | _ | |a Yoon, Sung-Soo |b 89 |
| 700 | 1 | _ | |a Zamora, Jorge |b 90 |
| 700 | 1 | _ | |a Zhang, Cheng-Zhong |b 91 |
| 773 | _ | _ | |a 10.1038/s41467-019-13824-9 |g Vol. 11, no. 1, p. 733 |0 PERI:(DE-600)2553671-0 |n 1 |p 733 |t Nature Communications |v 11 |y 2020 |x 2041-1723 |
| 909 | C | O | |p VDB |o oai:inrepo02.dkfz.de:153604 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 0 |6 P:(DE-He78)a82e5b3870b674f83ff39df31c487ac7 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 1 |6 P:(DE-He78)7f6d024a3ef1eee64b6a24c8fcc2a581 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 3 |6 P:(DE-HGF)0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 4 |6 P:(DE-He78)e053817bc90becc8a8dd8250e677e773 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 5 |6 P:(DE-He78)135e8c8d1dd1b66b8127c3d1e3a9b6a0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 6 |6 P:(DE-He78)5df998d953f664b5230be9553e48e293 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 9 |6 P:(DE-He78)36d0b1aeaf5a81ce289db680388c0adf |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 11 |6 P:(DE-He78)78b6aa82148e60b4d91e3a37a6d3d9a0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 12 |6 P:(DE-He78)f2a782242acf94a3114d75c45dc75b37 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 14 |6 P:(DE-He78)fc949170377b58098e46141d95c72661 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 15 |6 P:(DE-He78)94de5f7413279464b6e738d91dfae1eb |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 16 |6 P:(DE-He78)551bb92841f634070997aa168d818492 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 17 |6 P:(DE-He78)75e2afb3ea0812786cc551c10679b67d |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 25 |6 P:(DE-He78)fc949170377b58098e46141d95c72661 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 36 |6 P:(DE-He78)75e2afb3ea0812786cc551c10679b67d |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 45 |6 P:(DE-He78)135e8c8d1dd1b66b8127c3d1e3a9b6a0 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 47 |6 P:(DE-He78)551bb92841f634070997aa168d818492 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 70 |6 P:(DE-He78)94de5f7413279464b6e738d91dfae1eb |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 78 |6 P:(DE-He78)a82e5b3870b674f83ff39df31c487ac7 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 80 |6 P:(DE-He78)7483734fd8ab316391aa604c95f0e98a |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Krebsforschung |1 G:(DE-HGF)POF3-310 |0 G:(DE-HGF)POF3-312 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Functional and structural genomics |x 0 |
| 914 | 1 | _ | |y 2020 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b NAT COMMUN : 2017 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0320 |2 StatID |b PubMed Central |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0501 |2 StatID |b DOAJ Seal |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0500 |2 StatID |b DOAJ |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b DOAJ : Blind peer review |
| 915 | _ | _ | |a Creative Commons Attribution CC BY (No Version) |0 LIC:(DE-HGF)CCBYNV |2 V:(DE-HGF) |b DOAJ |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1060 |2 StatID |b Current Contents - Agriculture, Biology and Environmental Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1150 |2 StatID |b Current Contents - Physical, Chemical and Earth Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1040 |2 StatID |b Zoological Record |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a IF >= 10 |0 StatID:(DE-HGF)9910 |2 StatID |b NAT COMMUN : 2017 |
| 920 | 1 | _ | |0 I:(DE-He78)B330-20160331 |k B330 |l Angewandte Bioinformatik |x 0 |
| 920 | 1 | _ | |0 I:(DE-He78)B080-20160331 |k B080 |l Theoretische Bioinformatik |x 1 |
| 920 | 1 | _ | |0 I:(DE-He78)B066-20160331 |k B066 |l B066 Chromatin-Netzwerke |x 2 |
| 920 | 1 | _ | |0 I:(DE-He78)B240-20160331 |k B240 |l Bioinformatik und Omics Data Analytics |x 3 |
| 920 | 1 | _ | |0 I:(DE-He78)HD01-20160331 |k HD01 |l DKTK HD zentral |x 4 |
| 920 | 1 | _ | |0 I:(DE-He78)B062-20160331 |k B062 |l B062 Pädiatrische Neuroonkologie |x 5 |
| 920 | 1 | _ | |0 I:(DE-He78)B360-20160331 |k B360 |l Pediatric Glioma |x 6 |
| 920 | 1 | _ | |0 I:(DE-He78)B063-20160331 |k B063 |l B063 Krebsgenomforschung |x 7 |
| 920 | 0 | _ | |0 I:(DE-He78)B340-20160331 |k B340 |l Translationale Medizinische Onkologie |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)B330-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B080-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B066-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B240-20160331 |
| 980 | _ | _ | |a I:(DE-He78)HD01-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B062-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B360-20160331 |
| 980 | _ | _ | |a I:(DE-He78)B063-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|