%0 Journal Article
%A Ochoa-Rosales, Carolina
%A Portilla-Fernandez, Eliana
%A Nano, Jana
%A Wilson, Rory
%A Lehne, Benjamin
%A Mishra, Pashupati P
%A Gao, Xu
%A Ghanbari, Mohsen
%A Rueda-Ochoa, Oscar L
%A Juvinao-Quintero, Diana
%A Loh, Marie
%A Zhang, Weihua
%A Kooner, Jaspal S
%A Grabe, Hans J
%A Felix, Stephan B
%A Schöttker, Ben
%A Zhang, Yan
%A Gieger, Christian
%A Müller-Nurasyid, Martina
%A Heier, Margit
%A Peters, Annette
%A Lehtimäki, Terho
%A Teumer, Alexander
%A Brenner, Hermann
%A Waldenberger, Melanie
%A Ikram, M Arfan
%A van Meurs, Joyce B J
%A Franco, Oscar H
%A Voortman, Trudy
%A Chambers, John
%A Stricker, Bruno H
%A Muka, Taulant
%T Epigenetic Link Between Statin Therapy and Type 2 Diabetes.
%J Diabetes care
%V 43
%N 4
%@ 1935-5548
%C Alexandria, Va.
%I Assoc.
%M DKFZ-2020-00376
%P 875-884
%D 2020
%Z 2020 Apr;43(4):875-884
%X To investigate the role of epigenetics in statins' diabetogenic effect comparing DNA methylation (DNAm) between statin users and nonusers in an epigenome-wide association study in blood.Five cohort studies' participants (n = 8,270) were classified as statin users when they were on statin therapy at the time of DNAm assessment with Illumina 450K or EPIC array or noncurrent users otherwise. Associations of DNAm with various outcomes like incident type 2 diabetes, plasma glucose, insulin, and insulin resistance (HOMA of insulin resistance [HOMA-IR]) as well as with gene expression were investigated.Discovery (n = 6,820) and replication (n = 1,450) phases associated five DNAm sites with statin use: cg17901584 (1.12 × 10-25 [DHCR24]), cg10177197 (3.94 × 10-08 [DHCR24]), cg06500161 (2.67 × 10-23 [ABCG1]), cg27243685 (6.01 × 10-09 [ABCG1]), and cg05119988 (7.26 × 10-12 [SC4MOL]). Two sites were associated with at least one glycemic trait or type 2 diabetes. Higher cg06500161 methylation was associated with higher fasting glucose, insulin, HOMA-IR, and type 2 diabetes (odds ratio 1.34 [95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32033992
%R 10.2337/dc19-1828
%U https://inrepo02.dkfz.de/record/153653