TY  - JOUR
AU  - Ochoa-Rosales, Carolina
AU  - Portilla-Fernandez, Eliana
AU  - Nano, Jana
AU  - Wilson, Rory
AU  - Lehne, Benjamin
AU  - Mishra, Pashupati P
AU  - Gao, Xu
AU  - Ghanbari, Mohsen
AU  - Rueda-Ochoa, Oscar L
AU  - Juvinao-Quintero, Diana
AU  - Loh, Marie
AU  - Zhang, Weihua
AU  - Kooner, Jaspal S
AU  - Grabe, Hans J
AU  - Felix, Stephan B
AU  - Schöttker, Ben
AU  - Zhang, Yan
AU  - Gieger, Christian
AU  - Müller-Nurasyid, Martina
AU  - Heier, Margit
AU  - Peters, Annette
AU  - Lehtimäki, Terho
AU  - Teumer, Alexander
AU  - Brenner, Hermann
AU  - Waldenberger, Melanie
AU  - Ikram, M Arfan
AU  - van Meurs, Joyce B J
AU  - Franco, Oscar H
AU  - Voortman, Trudy
AU  - Chambers, John
AU  - Stricker, Bruno H
AU  - Muka, Taulant
TI  - Epigenetic Link Between Statin Therapy and Type 2 Diabetes.
JO  - Diabetes care
VL  - 43
IS  - 4
SN  - 1935-5548
CY  - Alexandria, Va.
PB  - Assoc.
M1  - DKFZ-2020-00376
SP  - 875-884
PY  - 2020
N1  - 2020 Apr;43(4):875-884
AB  - To investigate the role of epigenetics in statins' diabetogenic effect comparing DNA methylation (DNAm) between statin users and nonusers in an epigenome-wide association study in blood.Five cohort studies' participants (n = 8,270) were classified as statin users when they were on statin therapy at the time of DNAm assessment with Illumina 450K or EPIC array or noncurrent users otherwise. Associations of DNAm with various outcomes like incident type 2 diabetes, plasma glucose, insulin, and insulin resistance (HOMA of insulin resistance [HOMA-IR]) as well as with gene expression were investigated.Discovery (n = 6,820) and replication (n = 1,450) phases associated five DNAm sites with statin use: cg17901584 (1.12 × 10-25 [DHCR24]), cg10177197 (3.94 × 10-08 [DHCR24]), cg06500161 (2.67 × 10-23 [ABCG1]), cg27243685 (6.01 × 10-09 [ABCG1]), and cg05119988 (7.26 × 10-12 [SC4MOL]). Two sites were associated with at least one glycemic trait or type 2 diabetes. Higher cg06500161 methylation was associated with higher fasting glucose, insulin, HOMA-IR, and type 2 diabetes (odds ratio 1.34 [95
LB  - PUB:(DE-HGF)16
C6  - pmid:32033992
DO  - DOI:10.2337/dc19-1828
UR  - https://inrepo02.dkfz.de/record/153653
ER  -