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@ARTICLE{Sowah:153725,
      author       = {S. Sowah$^*$ and F. Hirche and A. Milanese and T. S.
                      Johnson$^*$ and M. Grafetstätter$^*$ and R. Schübel$^*$
                      and R. Kirsten and C. M. Ulrich and R. Kaaks$^*$ and G.
                      Zeller and T. Kühn$^*$ and G. I. Stangl},
      title        = {{C}hanges in {P}lasma {S}hort-{C}hain {F}atty {A}cid
                      {L}evels after {D}ietary {W}eight {L}oss {A}mong
                      {O}verweight and {O}bese {A}dults over 50 {W}eeks.},
      journal      = {Nutrients},
      volume       = {12},
      number       = {2},
      issn         = {2072-6643},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2020-00422},
      pages        = {452},
      year         = {2020},
      note         = {#EA:C020#},
      abstract     = {Gut microbial-derived short-chain fatty acids (SCFAs) may
                      regulate energy homeostasis and exert anti-carcinogenic,
                      immunomodulatory and anti-inflammatory effects. Smaller
                      trials indicate that dietary weight loss may lead to
                      decreased SCFA production, but findings have been
                      inconclusive. SCFA concentrations were measured by
                      HPLC-MS/MS in plasma samples of 150 overweight or obese
                      adults in a trial initially designed to evaluate the
                      metabolic effects of intermittent (ICR) versus continuous
                      (CCR) calorie restriction (NCT02449148). For the present
                      post hoc analyses, participants were classified by quartiles
                      of weight loss, irrespective of the dietary intervention.
                      Linear mixed models were used to analyze weight-loss-induced
                      changes in SCFA concentrations after 12, 24 and 50 weeks.
                      There were no differential changes in SCFA levels across the
                      initial study arms (ICR versus CCR versus control) after 12
                      weeks, but acetate concentrations significantly decreased
                      with overall weight loss (mean log-relative change of -0.7
                      ± 1.8 in the lowest quartile versus. -7.6 ± 2 in the
                      highest, p = 0.026). Concentrations of propionate, butyrate
                      and other SCFAs did not change throughout the study. Our
                      results show that weight-loss, achieved through calorie
                      restriction, may lead to smaller initial decreases in plasma
                      acetate, while plasma SCFAs generally remain remarkably
                      stable over time.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32053988},
      doi          = {10.3390/nu12020452},
      url          = {https://inrepo02.dkfz.de/record/153725},
}