000153735 001__ 153735
000153735 005__ 20240229123048.0
000153735 0247_ $$2doi$$a10.1038/s41588-019-0562-0
000153735 0247_ $$2pmid$$apmid:32024998
000153735 0247_ $$2ISSN$$a1061-4036
000153735 0247_ $$2ISSN$$a1546-1718
000153735 0247_ $$2altmetric$$aaltmetric:75074650
000153735 037__ $$aDKFZ-2020-00432
000153735 041__ $$aeng
000153735 082__ $$a570
000153735 1001_ $$00000-0003-4693-3140$$aRodriguez-Martin, Bernardo$$b0
000153735 245__ $$aPan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition.
000153735 260__ $$aLondon$$bMacmillan Publishers Limited, part of Springer Nature$$c2020
000153735 3367_ $$2DRIVER$$aarticle
000153735 3367_ $$2DataCite$$aOutput Types/Journal article
000153735 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1683703287_9238
000153735 3367_ $$2BibTeX$$aARTICLE
000153735 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000153735 3367_ $$00$$2EndNote$$aJournal Article
000153735 500__ $$a2020 Mar;52(3):306-319
000153735 520__ $$aAbout half of all cancers have somatic integrations of retrotransposons. Here, to characterize their role in oncogenesis, we analyzed the patterns and mechanisms of somatic retrotransposition in 2,954 cancer genomes from 38 histological cancer subtypes within the framework of the Pan-Cancer Analysis of Whole Genomes (PCAWG) project. We identified 19,166 somatically acquired retrotransposition events, which affected 35% of samples and spanned a range of event types. Long interspersed nuclear element (LINE-1; L1 hereafter) insertions emerged as the first most frequent type of somatic structural variation in esophageal adenocarcinoma, and the second most frequent in head-and-neck and colorectal cancers. Aberrant L1 integrations can delete megabase-scale regions of a chromosome, which sometimes leads to the removal of tumor-suppressor genes, and can induce complex translocations and large-scale duplications. Somatic retrotranspositions can also initiate breakage-fusion-bridge cycles, leading to high-level amplification of oncogenes. These observations illuminate a relevant role of L1 retrotransposition in remodeling the cancer genome, with potential implications for the development of human tumors.
000153735 536__ $$0G:(DE-HGF)POF3-312$$a312 - Functional and structural genomics (POF3-312)$$cPOF3-312$$fPOF III$$x0
000153735 588__ $$aDataset connected to CrossRef, PubMed,
000153735 7001_ $$aAlvarez, Eva G$$b1
000153735 7001_ $$aBaez-Ortega, Adrian$$b2
000153735 7001_ $$aZamora, Jorge$$b3
000153735 7001_ $$00000-0002-7811-6711$$aSupek, Fran$$b4
000153735 7001_ $$00000-0002-2660-2478$$aDemeulemeester, Jonas$$b5
000153735 7001_ $$aSantamarina, Martin$$b6
000153735 7001_ $$00000-0002-5514-4189$$aJu, Young Seok$$b7
000153735 7001_ $$00000-0003-3370-4728$$aTemes, Javier$$b8
000153735 7001_ $$00000-0002-0997-8799$$aGarcia-Souto, Daniel$$b9
000153735 7001_ $$aDetering, Harald$$b10
000153735 7001_ $$aLi, Yilong$$b11
000153735 7001_ $$aRodriguez-Castro, Jorge$$b12
000153735 7001_ $$aDueso-Barroso, Ana$$b13
000153735 7001_ $$aBruzos, Alicia L$$b14
000153735 7001_ $$0P:(DE-He78)40af5fd3ec583f9dc5da1c7c7e00524f$$aDentro, Stefan$$b15
000153735 7001_ $$00000-0002-2883-7326$$aBlanco, Miguel G$$b16
000153735 7001_ $$aContino, Gianmarco$$b17
000153735 7001_ $$00000-0002-5593-421X$$aArdeljan, Daniel$$b18
000153735 7001_ $$aTojo, Marta$$b19
000153735 7001_ $$00000-0002-0469-1043$$aRoberts, Nicola D$$b20
000153735 7001_ $$00000-0002-2108-1861$$aZumalave, Sonia$$b21
000153735 7001_ $$00000-0002-4789-3374$$aEdwards, Paul A W$$b22
000153735 7001_ $$aWeischenfeldt, Joachim$$b23
000153735 7001_ $$aPuiggròs, Montserrat$$b24
000153735 7001_ $$aChong, Zechen$$b25
000153735 7001_ $$00000-0003-4013-5279$$aChen, Ken$$b26
000153735 7001_ $$aLee, Eunjung Alice$$b27
000153735 7001_ $$00000-0001-6591-1620$$aWala, Jeremiah A$$b28
000153735 7001_ $$00000-0002-5634-1539$$aRaine, Keiran$$b29
000153735 7001_ $$aButler, Adam$$b30
000153735 7001_ $$aWaszak, Sebastian M$$b31
000153735 7001_ $$00000-0002-5640-9070$$aNavarro, Fabio C P$$b32
000153735 7001_ $$aSchumacher, Steven E$$b33
000153735 7001_ $$00000-0002-9737-5516$$aMonlong, Jean$$b34
000153735 7001_ $$aMaura, Francesco$$b35
000153735 7001_ $$aBolli, Niccolo$$b36
000153735 7001_ $$00000-0002-3933-9656$$aBourque, Guillaume$$b37
000153735 7001_ $$aGerstein, Mark$$b38
000153735 7001_ $$00000-0001-9378-960X$$aPark, Peter J$$b39
000153735 7001_ $$aWedge, David C$$b40
000153735 7001_ $$aBeroukhim, Rameen$$b41
000153735 7001_ $$aTorrents, David$$b42
000153735 7001_ $$aKorbel, Jan O$$b43
000153735 7001_ $$aMartincorena, Inigo$$b44
000153735 7001_ $$00000-0002-3434-3568$$aFitzgerald, Rebecca C$$b45
000153735 7001_ $$00000-0003-0292-1949$$aVan Loo, Peter$$b46
000153735 7001_ $$aKazazian, Haig H$$b47
000153735 7001_ $$00000-0003-1620-3761$$aBurns, Kathleen H$$b48
000153735 7001_ $$aGroup, PCAWG Structural Variation Working$$b49$$eCollaboration Author
000153735 7001_ $$00000-0002-3921-0510$$aCampbell, Peter J$$b50
000153735 7001_ $$00000-0003-3540-2459$$aTubio, Jose M C$$b51
000153735 7001_ $$aConsortium, PCAWG$$b52$$eCollaboration Author
000153735 7001_ $$aAkdemir, Kadir C$$b53
000153735 7001_ $$aAlvarez, Eva G$$b54
000153735 7001_ $$aBaez-Ortega, Adrian$$b55
000153735 7001_ $$aBeroukhim, Rameen$$b56
000153735 7001_ $$aBoutros, Paul C$$b57
000153735 7001_ $$aBowtell, David D L$$b58
000153735 7001_ $$0P:(DE-He78)fc949170377b58098e46141d95c72661$$aBrors, Benedikt$$b59
000153735 7001_ $$aBurns, Kathleen H$$b60
000153735 7001_ $$aCampbell, Peter J$$b61
000153735 7001_ $$aChan, Kin$$b62
000153735 7001_ $$aChen, Ken$$b63
000153735 7001_ $$aCortés-Ciriano, Isidro$$b64
000153735 7001_ $$aDueso-Barroso, Ana$$b65
000153735 7001_ $$aDunford, Andrew J$$b66
000153735 7001_ $$aEdwards, Paul A$$b67
000153735 7001_ $$aEstivill, Xavier$$b68
000153735 7001_ $$aEtemadmoghadam, Dariush$$b69
000153735 7001_ $$0P:(DE-He78)75e2afb3ea0812786cc551c10679b67d$$aFeuerbach, Lars$$b70
000153735 7001_ $$aFink, J Lynn$$b71
000153735 7001_ $$aFrenkel-Morgenstern, Milana$$b72
000153735 7001_ $$aGarsed, Dale W$$b73
000153735 7001_ $$aGerstein, Mark$$b74
000153735 7001_ $$aGordenin, Dmitry A$$b75
000153735 7001_ $$aHaan, David$$b76
000153735 7001_ $$aHaber, James E$$b77
000153735 7001_ $$aHess, Julian M$$b78
000153735 7001_ $$0P:(DE-He78)135e8c8d1dd1b66b8127c3d1e3a9b6a0$$aHutter, Barbara$$b79
000153735 7001_ $$aImielinski, Marcin$$b80
000153735 7001_ $$0P:(DE-He78)551bb92841f634070997aa168d818492$$aJones, David T W$$b81
000153735 7001_ $$aJu, Young Seok$$b82
000153735 7001_ $$aKazanov, Marat D$$b83
000153735 7001_ $$aKlimczak, Leszek J$$b84
000153735 7001_ $$aKoh, Youngil$$b85
000153735 7001_ $$aKorbel, Jan O$$b86
000153735 7001_ $$aKumar, Kiran$$b87
000153735 7001_ $$aLee, Eunjung Alice$$b88
000153735 7001_ $$aLee, Jake June-Koo$$b89
000153735 7001_ $$aLi, Yilong$$b90
000153735 7001_ $$aLynch, Andy G$$b91
000153735 7001_ $$aMacintyre, Geoff$$b92
000153735 7001_ $$aMarkowetz, Florian$$b93
000153735 7001_ $$aMartincorena, Iñigo$$b94
000153735 7001_ $$aMartinez-Fundichely, Alexander$$b95
000153735 7001_ $$aMeyerson, Matthew$$b96
000153735 7001_ $$aMiyano, Satoru$$b97
000153735 7001_ $$aNakagawa, Hidewaki$$b98
000153735 7001_ $$aNavarro, Fabio C P$$b99
000153735 7001_ $$aOssowski, Stephan$$b100
000153735 7001_ $$aPark, Peter J$$b101
000153735 7001_ $$aPearson, John V$$b102
000153735 7001_ $$aPuiggròs, Montserrat$$b103
000153735 7001_ $$0P:(DE-He78)94de5f7413279464b6e738d91dfae1eb$$aRippe, Karsten$$b104
000153735 7001_ $$aRoberts, Nicola D$$b105
000153735 7001_ $$aRoberts, Steven A$$b106
000153735 7001_ $$aRodriguez-Martin, Bernardo$$b107
000153735 7001_ $$aSchumacher, Steven E$$b108
000153735 7001_ $$aScully, Ralph$$b109
000153735 7001_ $$aShackleton, Mark$$b110
000153735 7001_ $$aSidiropoulos, Nikos$$b111
000153735 7001_ $$0P:(DE-He78)a82e5b3870b674f83ff39df31c487ac7$$aSieverling, Lina$$b112
000153735 7001_ $$aStewart, Chip$$b113
000153735 7001_ $$0P:(DE-He78)7483734fd8ab316391aa604c95f0e98a$$aSültmann, Holger$$b114$$udkfz
000153735 7001_ $$aTorrents, David$$b115
000153735 7001_ $$aTubio, Jose M C$$b116
000153735 7001_ $$aVillasante, Izar$$b117
000153735 7001_ $$aWaddell, Nicola$$b118
000153735 7001_ $$aWala, Jeremiah A$$b119
000153735 7001_ $$aWeischenfeldt, Joachim$$b120
000153735 7001_ $$aYang, Lixing$$b121
000153735 7001_ $$aYao, Xiaotong$$b122
000153735 7001_ $$aYoon, Sung-Soo$$b123
000153735 7001_ $$aZamora, Jorge$$b124
000153735 7001_ $$aZhang, Cheng-Zhong$$b125
000153735 773__ $$0PERI:(DE-600)1494946-5$$a10.1038/s41588-019-0562-0$$n3$$p306-319$$tNature genetics$$v52$$x1546-1718$$y2020
000153735 909CO $$ooai:inrepo02.dkfz.de:153735$$pVDB
000153735 9101_ $$0I:(DE-HGF)0$$6P:(DE-He78)40af5fd3ec583f9dc5da1c7c7e00524f$$aExternal Institute$$b15$$kExtern
000153735 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)fc949170377b58098e46141d95c72661$$aDeutsches Krebsforschungszentrum$$b59$$kDKFZ
000153735 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)75e2afb3ea0812786cc551c10679b67d$$aDeutsches Krebsforschungszentrum$$b70$$kDKFZ
000153735 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)135e8c8d1dd1b66b8127c3d1e3a9b6a0$$aDeutsches Krebsforschungszentrum$$b79$$kDKFZ
000153735 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)551bb92841f634070997aa168d818492$$aDeutsches Krebsforschungszentrum$$b81$$kDKFZ
000153735 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)94de5f7413279464b6e738d91dfae1eb$$aDeutsches Krebsforschungszentrum$$b104$$kDKFZ
000153735 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)a82e5b3870b674f83ff39df31c487ac7$$aDeutsches Krebsforschungszentrum$$b112$$kDKFZ
000153735 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)7483734fd8ab316391aa604c95f0e98a$$aDeutsches Krebsforschungszentrum$$b114$$kDKFZ
000153735 9131_ $$0G:(DE-HGF)POF3-312$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vFunctional and structural genomics$$x0
000153735 9141_ $$y2020
000153735 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000153735 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000153735 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000153735 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNAT GENET : 2017
000153735 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000153735 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000153735 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000153735 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000153735 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000153735 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000153735 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000153735 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000153735 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000153735 915__ $$0StatID:(DE-HGF)9925$$2StatID$$aIF >= 25$$bNAT GENET : 2017
000153735 9201_ $$0I:(DE-He78)B330-20160331$$kB330$$lAngewandte Bioinformatik$$x0
000153735 9201_ $$0I:(DE-He78)B360-20160331$$kB360$$lPediatric Glioma$$x1
000153735 9201_ $$0I:(DE-He78)B066-20160331$$kB066$$lB066 Chromatin-Netzwerke$$x2
000153735 9201_ $$0I:(DE-He78)B340-20160331$$kB340$$lTranslationale Medizinische Onkologie$$x3
000153735 9201_ $$0I:(DE-He78)HD01-20160331$$kHD01$$lDKTK HD zentral$$x4
000153735 9201_ $$0I:(DE-He78)B063-20160331$$kB063$$lB063 Krebsgenomforschung$$x5
000153735 980__ $$ajournal
000153735 980__ $$aVDB
000153735 980__ $$aI:(DE-He78)B330-20160331
000153735 980__ $$aI:(DE-He78)B360-20160331
000153735 980__ $$aI:(DE-He78)B066-20160331
000153735 980__ $$aI:(DE-He78)B340-20160331
000153735 980__ $$aI:(DE-He78)HD01-20160331
000153735 980__ $$aI:(DE-He78)B063-20160331
000153735 980__ $$aUNRESTRICTED