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@ARTICLE{RodriguezMartin:153735,
      author       = {B. Rodriguez-Martin and E. G. Alvarez and A. Baez-Ortega
                      and J. Zamora and F. Supek and J. Demeulemeester and M.
                      Santamarina and Y. S. Ju and J. Temes and D. Garcia-Souto
                      and H. Detering and Y. Li and J. Rodriguez-Castro and A.
                      Dueso-Barroso and A. L. Bruzos and S. Dentro and M. G.
                      Blanco and G. Contino and D. Ardeljan and M. Tojo and N. D.
                      Roberts and S. Zumalave and P. A. W. Edwards and J.
                      Weischenfeldt and M. Puiggròs and Z. Chong and K. Chen and
                      E. A. Lee and J. A. Wala and K. Raine and A. Butler and S.
                      M. Waszak and F. C. P. Navarro and S. E. Schumacher and J.
                      Monlong and F. Maura and N. Bolli and G. Bourque and M.
                      Gerstein and P. J. Park and D. C. Wedge and R. Beroukhim and
                      D. Torrents and J. O. Korbel and I. Martincorena and R. C.
                      Fitzgerald and P. Van Loo and H. H. Kazazian and K. H. Burns
                      and P. J. Campbell and J. M. C. Tubio and K. C. Akdemir and
                      E. G. Alvarez and A. Baez-Ortega and R. Beroukhim and P. C.
                      Boutros and D. D. L. Bowtell and B. Brors$^*$ and K. H.
                      Burns and P. J. Campbell and K. Chan and K. Chen and I.
                      Cortés-Ciriano and A. Dueso-Barroso and A. J. Dunford and
                      P. A. Edwards and X. Estivill and D. Etemadmoghadam and L.
                      Feuerbach$^*$ and J. L. Fink and M. Frenkel-Morgenstern and
                      D. W. Garsed and M. Gerstein and D. A. Gordenin and D. Haan
                      and J. E. Haber and J. M. Hess and B. Hutter$^*$ and M.
                      Imielinski and D. T. W. Jones$^*$ and Y. S. Ju and M. D.
                      Kazanov and L. J. Klimczak and Y. Koh and J. O. Korbel and
                      K. Kumar and E. A. Lee and J. J. Lee and Y. Li and A. G.
                      Lynch and G. Macintyre and F. Markowetz and I. Martincorena
                      and A. Martinez-Fundichely and M. Meyerson and S. Miyano and
                      H. Nakagawa and F. C. P. Navarro and S. Ossowski and P. J.
                      Park and J. V. Pearson and M. Puiggròs and K. Rippe$^*$ and
                      N. D. Roberts and S. A. Roberts and B. Rodriguez-Martin and
                      S. E. Schumacher and R. Scully and M. Shackleton and N.
                      Sidiropoulos and L. Sieverling$^*$ and C. Stewart and H.
                      Sültmann$^*$ and D. Torrents and J. M. C. Tubio and I.
                      Villasante and N. Waddell and J. A. Wala and J.
                      Weischenfeldt and L. Yang and X. Yao and S.-S. Yoon and J.
                      Zamora and C.-Z. Zhang},
      collaboration = {P. S. V. W. Group and P. Consortium},
      title        = {{P}an-cancer analysis of whole genomes identifies driver
                      rearrangements promoted by {LINE}-1 retrotransposition.},
      journal      = {Nature genetics},
      volume       = {52},
      number       = {3},
      issn         = {1546-1718},
      address      = {London},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DKFZ-2020-00432},
      pages        = {306-319},
      year         = {2020},
      note         = {2020 Mar;52(3):306-319},
      abstract     = {About half of all cancers have somatic integrations of
                      retrotransposons. Here, to characterize their role in
                      oncogenesis, we analyzed the patterns and mechanisms of
                      somatic retrotransposition in 2,954 cancer genomes from
                      38 histological cancer subtypes within the framework of
                      the Pan-Cancer Analysis of Whole Genomes (PCAWG) project. We
                      identified 19,166 somatically acquired retrotransposition
                      events, which affected $35\%$ of samples and spanned a range
                      of event types. Long interspersed nuclear element (LINE-1;
                      L1 hereafter) insertions emerged as the first most frequent
                      type of somatic structural variation in esophageal
                      adenocarcinoma, and the second most frequent in
                      head-and-neck and colorectal cancers. Aberrant L1
                      integrations can delete megabase-scale regions of a
                      chromosome, which sometimes leads to the removal of
                      tumor-suppressor genes, and can induce complex
                      translocations and large-scale duplications. Somatic
                      retrotranspositions can also initiate breakage-fusion-bridge
                      cycles, leading to high-level amplification of oncogenes.
                      These observations illuminate a relevant role of L1
                      retrotransposition in remodeling the cancer genome, with
                      potential implications for the development of human tumors.},
      cin          = {B330 / B360 / B066 / B340 / HD01 / B063},
      ddc          = {570},
      cid          = {I:(DE-He78)B330-20160331 / I:(DE-He78)B360-20160331 /
                      I:(DE-He78)B066-20160331 / I:(DE-He78)B340-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)B063-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32024998},
      doi          = {10.1038/s41588-019-0562-0},
      url          = {https://inrepo02.dkfz.de/record/153735},
}