000153753 001__ 153753
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000153753 0247_ $$2doi$$a10.1038/s41588-019-0564-y
000153753 0247_ $$2pmid$$apmid:32024999
000153753 0247_ $$2ISSN$$a1061-4036
000153753 0247_ $$2ISSN$$a1546-1718
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000153753 037__ $$aDKFZ-2020-00438
000153753 041__ $$aeng
000153753 082__ $$a570
000153753 1001_ $$aAkdemir, Kadir C$$b0
000153753 245__ $$aDisruption of chromatin folding domains by somatic genomic rearrangements in human cancer.
000153753 260__ $$aLondon$$bMacmillan Publishers Limited, part of Springer Nature$$c2020
000153753 3367_ $$2DRIVER$$aarticle
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000153753 500__ $$a2020 Mar;52(3):294-305
000153753 520__ $$aChromatin is folded into successive layers to organize linear DNA. Genes within the same topologically associating domains (TADs) demonstrate similar expression and histone-modification profiles, and boundaries separating different domains have important roles in reinforcing the stability of these features. Indeed, domain disruptions in human cancers can lead to misregulation of gene expression. However, the frequency of domain disruptions in human cancers remains unclear. Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), which aggregated whole-genome sequencing data from 2,658 cancers across 38 tumor types, we analyzed 288,457 somatic structural variations (SVs) to understand the distributions and effects of SVs across TADs. Notably, SVs can lead to the fusion of discrete TADs, and complex rearrangements markedly change chromatin folding maps in the cancer genomes. Notably, only 14% of the boundary deletions resulted in a change in expression in nearby genes of more than twofold.
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000153753 7001_ $$aLe, Victoria T$$b1
000153753 7001_ $$aChandran, Sahaana$$b2
000153753 7001_ $$aLi, Yilong$$b3
000153753 7001_ $$aVerhaak, Roel G$$b4
000153753 7001_ $$aBeroukhim, Rameen$$b5
000153753 7001_ $$aCampbell, Peter J$$b6
000153753 7001_ $$aChin, Lynda$$b7
000153753 7001_ $$aDixon, Jesse R$$b8
000153753 7001_ $$00000-0001-8663-2671$$aFutreal, P Andrew$$b9
000153753 7001_ $$aGroup, PCAWG Structural Variation Working$$b10$$eCollaboration Author
000153753 7001_ $$aConsortium, PCAWG$$b11$$eCollaboration Author
000153753 7001_ $$aAkdemir, Kadir C$$b12
000153753 7001_ $$aAlvarez, Eva G$$b13
000153753 7001_ $$aBaez-Ortega, Adrian$$b14
000153753 7001_ $$aBeroukhim, Rameen$$b15
000153753 7001_ $$aBoutros, Paul C$$b16
000153753 7001_ $$aBowtell, David D L$$b17
000153753 7001_ $$0P:(DE-He78)fc949170377b58098e46141d95c72661$$aBrors, Benedikt$$b18
000153753 7001_ $$aBurns, Kathleen H$$b19
000153753 7001_ $$aCampbell, Peter J$$b20
000153753 7001_ $$aChan, Kin$$b21
000153753 7001_ $$aChen, Ken$$b22
000153753 7001_ $$aCortés-Ciriano, Isidro$$b23
000153753 7001_ $$aDueso-Barroso, Ana$$b24
000153753 7001_ $$aDunford, Andrew J$$b25
000153753 7001_ $$aEdwards, Paul A$$b26
000153753 7001_ $$aEstivill, Xavier$$b27
000153753 7001_ $$aEtemadmoghadam, Dariush$$b28
000153753 7001_ $$0P:(DE-He78)75e2afb3ea0812786cc551c10679b67d$$aFeuerbach, Lars$$b29
000153753 7001_ $$aFink, J Lynn$$b30
000153753 7001_ $$aFrenkel-Morgenstern, Milana$$b31
000153753 7001_ $$aGarsed, Dale W$$b32
000153753 7001_ $$aGerstein, Mark$$b33
000153753 7001_ $$aGordenin, Dmitry A$$b34
000153753 7001_ $$aHaan, David$$b35
000153753 7001_ $$aHaber, James E$$b36
000153753 7001_ $$aHess, Julian M$$b37
000153753 7001_ $$0P:(DE-He78)135e8c8d1dd1b66b8127c3d1e3a9b6a0$$aHutter, Barbara$$b38
000153753 7001_ $$aImielinski, Marcin$$b39
000153753 7001_ $$0P:(DE-He78)551bb92841f634070997aa168d818492$$aJones, David T W$$b40
000153753 7001_ $$aJu, Young Seok$$b41
000153753 7001_ $$aKazanov, Marat D$$b42
000153753 7001_ $$aKlimczak, Leszek J$$b43
000153753 7001_ $$aKoh, Youngil$$b44
000153753 7001_ $$aKorbel, Jan O$$b45
000153753 7001_ $$aKumar, Kiran$$b46
000153753 7001_ $$aLee, Eunjung Alice$$b47
000153753 7001_ $$aLee, Jake June-Koo$$b48
000153753 7001_ $$aLi, Yilong$$b49
000153753 7001_ $$aLynch, Andy G$$b50
000153753 7001_ $$aMacintyre, Geoff$$b51
000153753 7001_ $$aMarkowetz, Florian$$b52
000153753 7001_ $$aMartincorena, Iñigo$$b53
000153753 7001_ $$aMartinez-Fundichely, Alexander$$b54
000153753 7001_ $$aMeyerson, Matthew$$b55
000153753 7001_ $$aMiyano, Satoru$$b56
000153753 7001_ $$aNakagawa, Hidewaki$$b57
000153753 7001_ $$aNavarro, Fabio C P$$b58
000153753 7001_ $$aOssowski, Stephan$$b59
000153753 7001_ $$aPark, Peter J$$b60
000153753 7001_ $$aPearson, John V$$b61
000153753 7001_ $$aPuiggròs, Montserrat$$b62
000153753 7001_ $$0P:(DE-He78)94de5f7413279464b6e738d91dfae1eb$$aRippe, Karsten$$b63
000153753 7001_ $$aRoberts, Nicola D$$b64
000153753 7001_ $$aRoberts, Steven A$$b65
000153753 7001_ $$aRodriguez-Martin, Bernardo$$b66
000153753 7001_ $$aSchumacher, Steven E$$b67
000153753 7001_ $$aScully, Ralph$$b68
000153753 7001_ $$aShackleton, Mark$$b69
000153753 7001_ $$aSidiropoulos, Nikos$$b70
000153753 7001_ $$0P:(DE-He78)a82e5b3870b674f83ff39df31c487ac7$$aSieverling, Lina$$b71
000153753 7001_ $$aStewart, Chip$$b72
000153753 7001_ $$0P:(DE-He78)7483734fd8ab316391aa604c95f0e98a$$aSültmann, Holger$$b73$$udkfz
000153753 7001_ $$aTorrents, David$$b74
000153753 7001_ $$aTubio, Jose M C$$b75
000153753 7001_ $$aVillasante, Izar$$b76
000153753 7001_ $$aWaddell, Nicola$$b77
000153753 7001_ $$aWala, Jeremiah A$$b78
000153753 7001_ $$aWeischenfeldt, Joachim$$b79
000153753 7001_ $$aYang, Lixing$$b80
000153753 7001_ $$aYao, Xiaotong$$b81
000153753 7001_ $$aYoon, Sung-Soo$$b82
000153753 7001_ $$aZamora, Jorge$$b83
000153753 7001_ $$aZhang, Cheng-Zhong$$b84
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