TY  - JOUR
AU  - Akdemir, Kadir C
AU  - Le, Victoria T
AU  - Chandran, Sahaana
AU  - Li, Yilong
AU  - Verhaak, Roel G
AU  - Beroukhim, Rameen
AU  - Campbell, Peter J
AU  - Chin, Lynda
AU  - Dixon, Jesse R
AU  - Futreal, P Andrew
AU  - Akdemir, Kadir C
AU  - Alvarez, Eva G
AU  - Baez-Ortega, Adrian
AU  - Beroukhim, Rameen
AU  - Boutros, Paul C
AU  - Bowtell, David D L
AU  - Brors, Benedikt
AU  - Burns, Kathleen H
AU  - Campbell, Peter J
AU  - Chan, Kin
AU  - Chen, Ken
AU  - Cortés-Ciriano, Isidro
AU  - Dueso-Barroso, Ana
AU  - Dunford, Andrew J
AU  - Edwards, Paul A
AU  - Estivill, Xavier
AU  - Etemadmoghadam, Dariush
AU  - Feuerbach, Lars
AU  - Fink, J Lynn
AU  - Frenkel-Morgenstern, Milana
AU  - Garsed, Dale W
AU  - Gerstein, Mark
AU  - Gordenin, Dmitry A
AU  - Haan, David
AU  - Haber, James E
AU  - Hess, Julian M
AU  - Hutter, Barbara
AU  - Imielinski, Marcin
AU  - Jones, David T W
AU  - Ju, Young Seok
AU  - Kazanov, Marat D
AU  - Klimczak, Leszek J
AU  - Koh, Youngil
AU  - Korbel, Jan O
AU  - Kumar, Kiran
AU  - Lee, Eunjung Alice
AU  - Lee, Jake June-Koo
AU  - Li, Yilong
AU  - Lynch, Andy G
AU  - Macintyre, Geoff
AU  - Markowetz, Florian
AU  - Martincorena, Iñigo
AU  - Martinez-Fundichely, Alexander
AU  - Meyerson, Matthew
AU  - Miyano, Satoru
AU  - Nakagawa, Hidewaki
AU  - Navarro, Fabio C P
AU  - Ossowski, Stephan
AU  - Park, Peter J
AU  - Pearson, John V
AU  - Puiggròs, Montserrat
AU  - Rippe, Karsten
AU  - Roberts, Nicola D
AU  - Roberts, Steven A
AU  - Rodriguez-Martin, Bernardo
AU  - Schumacher, Steven E
AU  - Scully, Ralph
AU  - Shackleton, Mark
AU  - Sidiropoulos, Nikos
AU  - Sieverling, Lina
AU  - Stewart, Chip
AU  - Sültmann, Holger
AU  - Torrents, David
AU  - Tubio, Jose M C
AU  - Villasante, Izar
AU  - Waddell, Nicola
AU  - Wala, Jeremiah A
AU  - Weischenfeldt, Joachim
AU  - Yang, Lixing
AU  - Yao, Xiaotong
AU  - Yoon, Sung-Soo
AU  - Zamora, Jorge
AU  - Zhang, Cheng-Zhong
TI  - Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer.
JO  - Nature genetics
VL  - 52
IS  - 3
SN  - 1546-1718
CY  - London
PB  - Macmillan Publishers Limited, part of Springer Nature
M1  - DKFZ-2020-00438
SP  - 294-305
PY  - 2020
N1  - 2020 Mar;52(3):294-305
AB  - Chromatin is folded into successive layers to organize linear DNA. Genes within the same topologically associating domains (TADs) demonstrate similar expression and histone-modification profiles, and boundaries separating different domains have important roles in reinforcing the stability of these features. Indeed, domain disruptions in human cancers can lead to misregulation of gene expression. However, the frequency of domain disruptions in human cancers remains unclear. Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), which aggregated whole-genome sequencing data from 2,658 cancers across 38 tumor types, we analyzed 288,457 somatic structural variations (SVs) to understand the distributions and effects of SVs across TADs. Notably, SVs can lead to the fusion of discrete TADs, and complex rearrangements markedly change chromatin folding maps in the cancer genomes. Notably, only 14
LB  - PUB:(DE-HGF)16
C6  - pmid:32024999
DO  - DOI:10.1038/s41588-019-0564-y
UR  - https://inrepo02.dkfz.de/record/153753
ER  -